Results 31 to 40 of about 49,706 (217)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Study of Theoretical Analysis and Modelling of Microalgal Membrane Photobioreactors for Microalgal Biomass Production and Nutrient Removal

Membranes
This study presents a theoretical and mathematical analysis and modelling of the emerging microalgal membrane photobioreactors (M-MPBRs) for wastewater treatment.
Yichen Liao, Pedram Fatehi, Baoqiang Liao   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimising Galdieria sulphuraria ACUF 427 Biomass for Enhanced Urban Wastewater Treatment: Evaluating Pollutant Removal Efficiency, Algal Growth, and Phycocyanin Production

Phycology
Urban wastewater is composed of nutrients such as nitrogen and phosphorus, organic matter, heavy metals, pathogens, and micropollutants. If untreated, these contribute to eutrophication and environmental degradation.
Berhan Retta, Manuela Iovinella, Claudia Ciniglia   +2 more
doaj   +1 more source

Start-up of a nutrient removal system using Scenedesmus vacuolatus and Chlorella vulgaris biofilms

Bioresources and Bioprocessing, 2019
Microalgal biofilm-based technologies are of strong interest due to their high biomass concentrations and ability to remove nutrients from wastewater, utilize CO2 and produce secondary valuable products. This study investigated the biomass production and
Jairo Hernán Moreno Osorio, Gabriele Pinto, Antoninio Pollio, Luigi Frunzo, Piet Nicolaas Luc Lens, Giovanni Esposito   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Separating biological nutrient removal by EBPR-PN/A process to treat real municipal sewage

Water Research X
The separated biological nutrient removal for treating wastewater has drawn significant interest due to its energy-neutral or energy-positive nutrient removal pathways.
Jialin Li, Yongzhen Peng, Shuai Li, Shenhua Yang, Wanyi Feng, Qiong Zhang, Xiyao Li, Liang Zhang   +7 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparative Evaluation of Anode Materials for Electrochemical Treatment of Anaerobic Digestate: Ammonia, Phosphorus, COD and Turbidity Removal

Energies
This study assessed the performance of five anode materials (Fe, stainless steel (SS), Al, Zn, and Ti/RuO2–IrO2) in terms of the removal of ammonia, phosphorus, and turbidity from anaerobic digestate using a single-cell hybrid electrocoagulation (EC ...
Shuotian Li, Sankar Ganesh Palani, Maazuza Z. Othman   +2 more
doaj   +1 more source