Results 71 to 80 of about 526,165 (306)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Toward better estimates of the real-time individual amino acid requirements of growing-finishing pigs showing deviations from their typical feeding patterns

Animal, 2020
Pigs exposed to stressors might change their daily typical feeding intake pattern. The objective of this study was to develop a method for the early identification of deviations from an individual pig’s typical feeding patterns.
L. Hauschild, A.R. Kristensen, I. Andretta, A. Remus, L.S. Santos, C. Pomar   +5 more
doaj   +1 more source

Towards a breakthrough in nutrient recycling : State-of-the-art and recommendations for developing policy instruments in Finland [PDF]

, 2018
The report has been complemented on 11.9.2018This report describes the state-of-the-art in phosphorus and nitrogen recycling in Finland and looks at basic data on the volumes and geographical distribution of biomasses and their nutrients.
Grönroos, Juha, Iho, Antti, Kauppila, Jussi, Koikkalainen, Kauko, Koskiaho, Jari, Laine-Ylijoki, Jutta, Lantto, Raija, Lehtonen, Eeva, Luostarinen, Sari, Marttinen, Sanna, Oasmaa, Anja, Rasa, Kimmo, Sarvi, Minna, Tampio, Elina, Turtola, Eila, Valve, Helena, Venelampi, Olli, Ylivainio, Kari, zu Castell-Rüdenhausen, Malin   +18 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Incorporating Environmentally Compliant Manure Nutrient Disposal Costs into Least-Cost Livestock Ration Formulation [PDF]

Livestock rations are formulated to minimize feed cost subject to nutritional requirements for a target performance level, which ignores the potentially substantial cost of disposing of nutrients fed in excess of nutritional requirements.
Black, J. Roy, Hadrich, Joleen C., Harsh, Stephen B., Wolf, Christopher A.   +3 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Precision feeding can significantly reduce lysine intake and nitrogen excretion without compromising the performance of growing pigs

Animal, 2016
This study was developed to assess the impact on performance, nutrient balance, serum parameters and feeding costs resulting from the switching of conventional to precision-feeding programs for growing–finishing pigs.
I. Andretta, C. Pomar, J. Rivest, J. Pomar, J. Radünz   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Requerimientos nutricionales de cabras lecheras. II. Proteína metabolizable

Agronomía Mesoamericana, 2007
Requerimientos nutricionales de cabras lecheras. II. Proteína metabolizable. El objetivo de este trabajo es presentar un extracto de los requerimientos nutricionales de proteína metabolizable de cabras lecheras a partir de la reciente publicación del ...
Jorge Alberto Elizondo-Salazar
doaj   +1 more source