Results 81 to 90 of about 693,986 (301)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Carrot or stick? – Would information concerning the economic value of nutrient losses, and their impact on food quality achieve greater environmental protection than regulation? [PDF]

, 2002
This report was presented at the UK Organic Research 2002 Conference. Organic standards have, since their origin (Soil Association 1967) required high standards of manure management, but in reality, these have not been implemented, possibly because of ...
Fowler, Susan M, Philipps, Lois, Watson, Christine A   +2 more
core  

Leaf-applied sodium chloride promotes cadmium accumulation in durum wheat grain [PDF]

, 2007
Cadmium (Cd) accumulation in durum wheat grain is a growing concern. Among the factors affecting Cd accumulation in plants, soil chloride (Cl) concentration plays a critical role.
DR Parker, DY Chan, E Schlichting, E Smolders, E Smolders, E Smolders, Faruk Ozkutlu, FT Bingham, FT Bingham, G Cieśliński, H Marschner, Halil Erdem, I Cakmak, I Cakmak, Ismail Cakmak, J Gutknecht, J Schonherr, J Wu, J Yanai, JJ Hart, JJ Hart, JJ Hart, JM Clarke, K Weggler, KR Dunbar, L Girault, L Ozturk, Levent Ozturk, M Greger, Mike McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, ML Adams, ML Jackson, NS Harris, PJ Florijn, R Munns, RM Welch, U Schmidt, UJ Lopez-Chuken, WA Norvell, WL Lindsay, Y Li, YM Li   +45 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Deficiência nutricional em mudas de umbuzeiro decorrente da omissão de macronutrientes Nutritional deficiency in "umbuzeiro" seedlings caused by the omission of macronutrients

Pesquisa Agropecuária Brasileira, 2006
O objetivo deste trabalho foi avaliar o crescimento e os sintomas visuais de deficiência de macronutrientes em mudas de umbuzeiro, Spondias tuberosa, cultivadas em solução nutritiva completa e com omissão individual de N, P, K, Ca, Mg e S.
Francisco César Gonçalves, Orlando Sílvio Caires Neves, Janice Guedes de Carvalho   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Effectiveness of Chemical Sanitizers against Salmonella Typhimurium in Nutrient Film Technique (NFT) Hydroponic Systems: Implications for Food Safety, Crop Quality, and Nutrient Content in Leafy Greens

Foods
Hydroponic farming systems play an increasingly important role in the sustainable production of nutrient-rich foods. The contamination of surfaces in hydroponic fresh produce production poses risks to the food safety of crops, potentially endangering ...
Abigail A. Mensah, Melanie L. Lewis Ivey, Margaret R. Moodispaw, Sanja Ilic   +3 more
doaj   +1 more source

Effects of the concentration of nutrient solution on lettuce growth in hydroponics-NFT system [PDF]

, 2008
Foi avaliado o crescimento da alface (Lactuca sativa L.) cv 'Vera' em um sistema hidropônico NFT com diferentes concentrações da solução nutritiva. O experimento foi realizado em casa de vegetação de abril a maio de 2000, na UFRRJ, Seropédica (RJ).
COMETTI, Nilton Nélio, FERNANDES, Manlio S, MARY, Wellington, MATIAS, Gean Carlos S, ZONTA, Everaldo   +4 more
core   +2 more sources

Nutrient Solutions for Orchids

Annals of the Missouri Botanical Garden, 1933
In a previous paper ('33) the author reported the result of growing seedlings of Cattleya Trianae Linden & Rchb. f., on three-salt solutions of various ratios, all having a total osmotic concentration of one atmosphere. It was found that the best growth was associated with solutions having low concentrations of phosphate ions.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source