Results 141 to 150 of about 5,960,150 (350)

Straw return decreases N surface runoff losses in croplands: Evidence from a global meta-analysis

Agricultural Water Management
Agricultural non-point source pollution, caused by Nitrogen (N) surface runoff losses, threatens green development and rural environmental quality. Straw return could reduce N losses by improving soil structure and N retention.
Xinyi Shi, Liangping Wu, Jing Xiang, Hongxu Liang, Ruibo Sun, Yusef Kianpoor Kalkhajeh, Zhi Wang, Heng Fang, Chao Ma   +8 more
doaj   +1 more source

Effects of replacing plant proteins with rubber seed meal on growth, nutrient utilization and blood biochemical parameters of tilapia (Oreochromis niloticus × O. aureus)

, 2017
An 8-week feeding trial was conducted to evaluate the effects of replacing plant proteins with rubber seed meal (RSM) on growth, nutrient utilization and blood biochemical parameters of juvenile tilapia (Oreochromis niloticus × O. aureus).
Deng Junming, Yan Wang, Liqiao Chen, K. Mai, Z. Wang, Xindang Zhang   +5 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Long-term biochar addition improves post-rice wheat production by ameliorating soil mechanical impedance and moisture condition as well as promoting root growth

Agricultural Water Management
Biochar has been widely applied as an efficiency soil additive to modify the quality of cultivated field. However, the effects of long-term biochar addition on spatial and temporal dynamics of soil compaction, and the changes in soil moisture condition ...
Zhi Wang, Wei Ma, Yunfei Lu, Xinyu Liu, Jiawen Han, Xinxin Ye   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Microbiome convergence enables siderophore-secreting-rhizobacteria to improve iron nutrition and yield of peanut intercropped with maize

Nature Communications
Intercropping has the potential to improve plant nutrition as well as crop yield. However, the exact mechanism promoting improved nutrient acquisition and the role the rhizosphere microbiome may play in this process remains poorly understood.
Nanqi Wang, Tianqi Wang, Yu Chen, Ming Wang, Qiaofang Lu, Kunguang Wang, Zhechao Dou, Zhiguang Chi, Wei Qiu, Jing Dai, Lei Niu, Jianyu Cui, Zhong Wei, Fusuo Zhang, Rolf Kümmerli, Yuanmei Zuo   +15 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Effect of combined nitrogen and phosphorus fertilization on summer maize yield and soil fertility in coastal saline-alkali land

Agricultural Water Management
Soil salinization limits food production and land use efficiency. Proper nitrogen and phosphate fertilizer application can improve saline soils, but the optimal ratio under saline-alkali conditions is unclear.
Changjian Ma, Wu Wenbiao, Peng Hou, Yue Wang, Bowen Li, Huabin Yuan, Lining Liu, Xuejun Wang, Zeqiang Sun, Yan Li   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source