Results 41 to 50 of about 105,245 (311)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Response of vegetation to sheep dung addition in a degraded Cerrado area
Revista Brasileira de Engenharia Agrícola e AmbientalCerrado is the second largest biome in Brazil and is classified as a biodiversity hotspot. The establishment of hydroelectric power stations in Brazil originated degraded areas due to the removal of soil for construction of dams, in which native ...
Danilo S. Teixeira +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Nutrients and Muscle Disease [PDF]
BioMed Research International, 2015 Myopathies, classified as either hereditary or acquired, lead to common, clinically relevant complaints including fatigue, progressive strength loss, myalgias, and cramps. Important progress has been made in the comprehension of the molecular mechanisms underlying muscle diseases but, in the majority of cases, their clinical management is symptom ...
E. Nisoli, R. Grange, G. D'Antona
openaire +3 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Revista Brasileira de Ciência do Solo, 2013 As pastagens formam a base da pecuária brasileira; essas sofrem degradação em larga escala por deficiência de nitrogênio (N). O consórcio com leguminosas, além de fixar N, pode apresentar outros efeitos na fertilidade do solo como acidificação ou ...
André Barbosa Silva +4 more
doaj +1 more source
Agronomía Mesoamericana, 2021 Introducción. El quitosano y las rizobacterias promotoras del crecimiento vegetal son reconocidos bioestimulantes agrícolas por los beneficios biológicos que aportan a las plantas. Objetivo.
Daimy Costales-Menéndez +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Revista Brasileira de Ciência do Solo, 2014 Water degradation is strongly related to agricultural activity. The aim of this study was to evaluate the influence of land use and some environmental components on surface water quality in the Campestre catchment, located in Colombo, state of Parana ...
Karina Hacke Ribeiro +6 more
doaj +1 more source
, 2014 Key Messages "Nutrient adequacy, a result of consumption of sufficient amounts of all essential nutrients and energy to meet individual requirements, is a prerequisite for normal growth, development and health. " Two thirds or more of hospital patients suffer from malnutrition at initial presentation.
openaire +3 more sources