Results 101 to 110 of about 798,130 (316)
MethodsXCompound-specific stable isotope ratio analysis of oxygen isotopes in inorganic phosphate can be used to study biological phosphorus cycling and the transformation processes controlling the fate of phosphorus. However, methods for extraction of inorganic
Maria Monrad Rieckmann +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Pharmacological ResearchDepression is a common mental disorder, the effective treatment of which remains a challenging issue worldwide. The clinical pathogenesis of depression has been deeply explored, leading to the formulation of various pathogenic hypotheses.
Yishu Yin +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Calcium—Nutrient and Messenger [PDF]
Frontiers in Plant Science, 2019 Calcium is an essential element needed for growth and development of plants under both non-stressed and stress conditions. It thereby fulfills a dual function, being not only an important factor for cell wall and membrane stability, but also serving as a second messenger in many developmental and physiological processes, including the response of ...
openaire +5 more sources
, 2019 In Spain, 40% of children are overweight or obese. Television advertising is a widely acknowledged factor contributing to high-calorie food intake. This study longitudinally correlates some variables involved in childhood obesity prevention strategies in
Jiménez Morales, Mònika +6 more
core +1 more source
Nutrients in fish and possible associations with cardiovascular disease risk factors in metabolic syndrome [PDF]
, 2018 Non-communicable diseases (NSDs) are responsible for two-thirds of all deaths globally, whereas cardiovascular disease (CVD) alone counts for nearly half of them.
Småstuen, Milada Cvancarova +5 more
core +1 more source
Agrosystems, Geosciences & EnvironmentAmmonia (NH3) volatilization from urea‐based fertilizers reduces nitrogen use efficiency and contributes to atmospheric NH3 emissions and associated health risks.
Syam Dodla +2 more
doaj +1 more source
Roadmap for Australian wastewater nutrient recovery – Towards a sustainable circular economy
Desalination and Water TreatmentTapping into wastewater for nutrient recovery is largely missing from water policy and circular economy (CE) conversations, and in particular, its incorporation of machine learning (ML).
Allan Soo, Li Gao, Ho Kyong Shon
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source