Results 81 to 90 of about 798,658 (316)
ADPKD is a progressive cystic disorder characterized by increasing total kidney volume (TKV), declining kidney function, and limited disease-modifying options. Emerging preclinical and clinical evidence suggests metabolic interventions may influence cyst
Melina Messing +5 more
doaj +1 more source
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Food Advertising and Prevention of Childhood Obesity in Spain: Analysis of the Nutritional Value of the Products and Discursive Strategies Used in the Ads Most Viewed by Children from 2016 to 2018 [PDF]
In Spain, 40% of children are overweight or obese. Television advertising is a widely acknowledged factor contributing to high-calorie food intake. This study longitudinally correlates some variables involved in childhood obesity prevention strategies in
Jiménez Morales, Mònika +6 more
core +1 more source
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Biogeochemical nutrient cycles and nutrient management strategies [PDF]
Nutrient loading by riverine input into estuarine systems has increased by 6–50 times for the N load from pristine conditions to present, whereas a 18–180 times increase has been observed in the P load. Reductions in the ratio of N to P delivery has also occurred with time.
openaire +2 more sources
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Nutrients Utilization in Obese Individuals with and without Hypertriglyceridemia [PDF]
Background: Low fat utilization is linked to weight gain and to the presence of certain atherosclerosis markers. It is not clear whether the presence of hyperlipidemia can further affect nutrients utilization.
Montalcini, T. +13 more
core +1 more source
Oral iron plus ascorbic acid supplementation and martial status [PDF]
Raw data of the clinical trial NCT04078880. We enrolled older adults scheduled for hip/knee surgery and we randomized them to a pre-operative supplementation program with iron and L-ascorbic acid or to the control group.
Matteo Briguglio
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source

