Results 71 to 80 of about 903,910 (312)

Household Food Insecurity as a Predictor of Stunted Children and Overweight/Obese Mothers (SCOWT) in Urban Indonesia [PDF]

, 2018
Background: The double burden of malnutrition has been increasing in countries experiencing the nutrition transition. This study aimed to determine the relationship between household food insecurity and the double burden of malnutrition, defined as within-
Trias Mahmudiono, Andrias, Dini Ririn, Megatsari, Hario, Dini Andrias, Rosenkranz, Richard R., Dini Ririn Andrias, Nindya, Triska Susila, Triska Susila Nindya, Triska Nindya, Richard Rosenkranz, Mahmudiono, Trias, Richard R. Rosenkranz, Hario Megatsari   +12 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Acknowledgment to the Reviewers of Nutrients in 2022

, 2023
High-quality academic publishing is built on rigorous peer review [...
Nutrients Editorial Office Nutrients Editorial Office
core   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer

Nature Communications
Incidence of colorectal cancer (CRC) is increasing likely due to different mechanisms driving initiation and progression. The initial model proposed by Fearon and Vogelstein posits it as a multi-hit neoplasia, originating from adenomatous-polyps induced ...
Irene Herranz-Montoya, Mariana Angulo-Aguado, Cristian Perna, Sladjana Zagorac, Luis García-Jimeno, Solip Park, Nabil Djouder   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Postbiotics for preventing and treating common infectious diseases in children: A systematic review [PDF]

, 2020
Postbiotics have recently been tentatively defined as bioactive compounds produced during a fermentation process (including microbial cells, cell constituents and metabolites) that supports health and/or wellbeing.
Malagón-Rojas, Jeadran N., Seppo Salminen, Mantziari, Anastasia, Szajewska, Hania, Anastasia Mantziari, Hania Szajewska, Jeadran N. Malagón-Rojas, Salminen, Seppo   +7 more
core   +1 more source

A novel hepatocyte ketone production assay to help the selection of nutrients for the ketogenic diet treatment of epilepsy

Scientific Reports
The classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates for their ketogenic potential may ...
Hester Meeusen, Alessia Romagnolo, Sophie A. C. Holsink, Thijs J. M. van den Broek, Ardy van Helvoort, Jan A. Gorter, Erwin A. van Vliet, J. Martin Verkuyl, Jose P. Silva, Eleonora Aronica   +9 more
doaj   +1 more source

Halting cyst progression in ADPKD using long-term ketogenic metabolic therapy and supplementation with exogenous ketones and alkaline citrate—a case series

Frontiers in Nutrition
ADPKD is a progressive cystic disorder characterized by increasing total kidney volume (TKV), declining kidney function, and limited disease-modifying options. Emerging preclinical and clinical evidence suggests metabolic interventions may influence cyst
Melina Messing, Melina Messing, Emily Muensterman, Serena Marcon, Thomas Weimbs, Thomas Weimbs   +5 more
doaj   +1 more source