Results 61 to 70 of about 798,130 (316)

Nutrient Adequacy

, 2014
Key Messages "Nutrient adequacy, a result of consumption of sufficient amounts of all essential nutrients and energy to meet individual requirements, is a prerequisite for normal growth, development and health. " Two thirds or more of hospital patients suffer from malnutrition at initial presentation.
openaire   +3 more sources

Household Food Insecurity as a Predictor of Stunted Children and Overweight/Obese Mothers (SCOWT) in Urban Indonesia [PDF]

, 2018
Background: The double burden of malnutrition has been increasing in countries experiencing the nutrition transition. This study aimed to determine the relationship between household food insecurity and the double burden of malnutrition, defined as within-
Trias Mahmudiono, Andrias, Dini Ririn, Megatsari, Hario, Dini Andrias, Rosenkranz, Richard R., Dini Ririn Andrias, Nindya, Triska Susila, Triska Susila Nindya, Triska Nindya, Richard Rosenkranz, Mahmudiono, Trias, Richard R. Rosenkranz, Hario Megatsari   +12 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancer

Nature Communications
Incidence of colorectal cancer (CRC) is increasing likely due to different mechanisms driving initiation and progression. The initial model proposed by Fearon and Vogelstein posits it as a multi-hit neoplasia, originating from adenomatous-polyps induced ...
Irene Herranz-Montoya, Mariana Angulo-Aguado, Cristian Perna, Sladjana Zagorac, Luis García-Jimeno, Solip Park, Nabil Djouder   +6 more
doaj   +1 more source

Cold exposure reinstates NAD+ levels and attenuates hepatocellular carcinoma

Cell Stress
Cold exposure has been historically used for medicinal purposes, but its benefits and associated mechanisms in mammalian organisms still remain unclear.
Tatiana P Grazioso, Maria del Mar Rigual, Cristian Perna, Eduardo J Caleiras, Nabil Djouder   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Structural characteristics, antioxidant and immunological activities of polysaccharides from Ficus hirta Vahl based on different extraction methods

Industrial Crops and Products
Ficus hirta Vahl is a bioactive medicinal plant. However, the structural and functional differences of polysaccharides obtained through various extraction methods remain poorly understood, highlighting the need for further research to explore its ...
Ting Ju, Yishu Yin, Heqi Gao, Jiayu Wang, Guanjun Ye, Jiangfei Li, Yingchun Zhang, Fangjing Miao, Weihong Lu   +8 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A novel hepatocyte ketone production assay to help the selection of nutrients for the ketogenic diet treatment of epilepsy

Scientific Reports
The classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates for their ketogenic potential may ...
Hester Meeusen, Alessia Romagnolo, Sophie A. C. Holsink, Thijs J. M. van den Broek, Ardy van Helvoort, Jan A. Gorter, Erwin A. van Vliet, J. Martin Verkuyl, Jose P. Silva, Eleonora Aronica   +9 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source