Results 51 to 60 of about 798,130 (316)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Peanuts, aflatoxins and undernutrition in children in Sub-Saharan Africa

open access: yes, 2017
Peanuts (Arachis hypogaea) is an important and affordable source of protein in most of Sub-Saharan Africa (SSA) and a popular commodity and raw material for peanut butter, paste and cooking oil. It is a popular ingredient for foods used at the point of
Mupunga, Innocent   +7 more
core   +1 more source

Acknowledgment to the Reviewers of Nutrients in 2022

open access: yes, 2023
High-quality academic publishing is built on rigorous peer review [...
Nutrients Editorial Office Nutrients Editorial Office
core   +1 more source

Postbiotics for preventing and treating common infectious diseases in children: A systematic review [PDF]

open access: yes, 2020
Postbiotics have recently been tentatively defined as bioactive compounds produced during a fermentation process (including microbial cells, cell constituents and metabolites) that supports health and/or wellbeing.
Malagón-Rojas, Jeadran N.   +7 more
core   +1 more source

Estimating Excreted Nutrients to Improve Nutrient Management for Grazing System Dairy Farms

open access: yesAnimals, 2023
Improving nutrient management in grazing system dairy farms requires determining nutrient flows through animals, the placement of cows within farms and potential for collection, and the re-use and loss of nutrients.
Sharon R. Aarons   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Nutrients and Muscle Disease [PDF]

open access: yesBioMed Research International, 2015
Myopathies, classified as either hereditary or acquired, lead to common, clinically relevant complaints including fatigue, progressive strength loss, myalgias, and cramps. Important progress has been made in the comprehension of the molecular mechanisms underlying muscle diseases but, in the majority of cases, their clinical management is symptom ...
E. Nisoli, R. Grange, G. D'Antona
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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