Results 101 to 110 of about 279,111 (362)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Responses of a bacterial pathogen to phosphorus limitation of its aquatic invertebrate host [PDF]

, 2008
Host nutrition is thought to affect the establishment, persistence, and severity of pathogenic infections. Nutrient-deficient foods possibly benefit pathogens by constraining host immune function or benefit hosts by limiting parasite growth and ...
Ebert, D., Frost, P. C., Smith, V. H.
core   +3 more sources

The effect of adding non-conventional ingredients and hydrocolloids to desirable quality attributes of pasta. A Mini Review

Croatian Journal of Food Science and Technology, 2018
As consumption of pasta is becoming more popular especially among the school children, pasta will supply essential nutrition. Moreover, value addition of pasta with different non-conventional ingredients would be helpful in promoting utilization of
AMIR GULL, PRADYUMAN KUMAR, TARIQ AHMAD SAFAPURI, ASHWANI KUMAR KHAJURIA, ANURADHA GANDOTRA, ROMEE JAN   +5 more
doaj   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Nutrition Country Profile United Republic of Tanzania [PDF]

, 2008
Population, Economic, Tanzania, urbanization ...
Bader, Estelle, Kinabo, Joyce, Palma, Giulia   +2 more
core  

Establishing national food priority in Saudi Arabia: developing a priority matrix for food

Agriculture & Food Security
Background Food security is achieved when individuals have consistent and reliable physical, social, and economic access to adequate, safe, and nutritious food that meets their dietary requirements and supports a healthy life. Food security encompasses a
Ghadir Fallata, Omar Alhumaidan, Haya Alomran, Nahla Bawazeer, Randah Alqurashi   +4 more
doaj   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

The Economics of Traceability for Multi-Ingredient Products: A Network Approach [PDF]

The consumption of multi-ingredient foods is increasing across the globe as consumers spend less time preparing meals. Traceability is now extensively used to reduce information imperfections in food markets and recent EU law suggests it will be ...
Caswell, Julie A., Souza Monteiro, Diogo M.   +1 more
core   +1 more source

Determination of a representative food mass-to-surface area ratio (mF/A) for estimating migration values of food contact substances in single use food contact articles marketed in the United States

Frontiers in Food Science and Technology
When reviewing the safety of food packaging, safety assessors must determine the migration levels of a food contact substance (FCS) from the packaging into the contained food products.
Lauren M. Zhovmer, Andres M. GonzalezBonet, Madhur Garg, Allan B. Bailey, Kirk B. Arvidson   +4 more
doaj   +1 more source