Results 71 to 80 of about 9,737,016 (361)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy

European Journal of Medical Research
Background Probiotic interventions are increasingly considered for alleviating gastrointestinal disorders such as diarrhea, nausea, bloating, and epigastric discomfort.
Qingfang Zeng, Pingdong Li, Huaiyang Wu, Yunying Zhuang, Yonggang Zhang, Sanaz Asemani, Parmida Jamilian, Mehrdad Jamali, Haixia Yu   +8 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Indications for nutritional support. [PDF]

Gut, 1986
In this review different types of patients who usually require nutritional support are considered and recommendations made as to when nutritional support should be started, how long it should be continued, and which substrates should be preferentially used by which route.
openaire   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Development, Validity, and Reliability of an Easy-to-Use Nutrition Counseling Tool for Thai Outpatients with Liver Cirrhosis

Journal of Health Science and Medical Research (JHSMR)
Objective: We developed a simple nutritional counseling tool for adults with liver cirrhosis, aiming for doctors, nurses, and patients as the tool’s primary users.
Nicha Sukittiwarapun, Chaitong Churuangsuk, Thammasin Inviya, Pimsiri Sripongpun, Naichaya Chamroonkul   +4 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Advances in Understanding and Managing Refeeding Syndrome: A Comprehensive Review

Quality in Sport
BACKGROUND: Refeeding syndrome (RFS) is a potentially serious complication that can occur during the reintroduction of nutrition in individuals who have experienced a period of malnutrition or starvation.
Agata Mazur, Aleksy Bizan, Natalia Dąbrowska, Aleksandra Kublińska, Magdalena Madera, Krzysztof Marcinkowski, Sylwia Mazur, Emilia Nagórska, Karolina Strus, Roksana Zdunek   +9 more
doaj   +1 more source

Bedside Ultrasound Measurement of Rectus Femoris: A Tutorial for the Nutrition Support Clinician

Journal of Nutrition and Metabolism, 2017
Intensive care unit acquired weakness is a long-term consequence after critical illness; it has been related to muscle atrophy and can be considered as one of the main nutritional support challenges at the intensive care unit.
Carlos Alfredo Galindo Martín, Enrique Monares Zepeda, Octavio Augusto Lescas Méndez   +2 more
semanticscholar   +1 more source