Results 71 to 80 of about 7,953,758 (313)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

open access: yes
Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Enteral nutrition with medium-chain triglyceride compared to total parenteral nutrition in patient with chylothorax: an evidence based case report [PDF]

open access: yes
Introduction: Chylothorax is associated with longer length of stay, higher morbidity, mortality, and hospitalization cost. The main principle of chylothorax therapy is to reduce the chylous flow.
Wulandari, Yohannessa   +1 more
core   +1 more source

Probiotics and gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy

open access: yesEuropean Journal of Medical Research
Background Probiotic interventions are increasingly considered for alleviating gastrointestinal disorders such as diarrhea, nausea, bloating, and epigastric discomfort.
Qingfang Zeng   +8 more
doaj   +1 more source

Long-term indwelling trans-anal ileus tube placement and nursing management for an elderly patient with intestinal obstruction (1例高龄肠梗阻患者长期留置经肛型肠梗阻导管的护理体会)

open access: yes中西医结合护理
This article summarized the nursing practice of an elderly patient with acute exacerbation of chronic cholecystitis complicated by intestinal obstruction during long-term indwelling trans-anal ileus tube placement.
ZHANG Jia (张佳), SUN Xin (孙鑫)
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

A comparison of nutritional status by intensive nutritional support in enteral nutrition patients

open access: yes, 2018
Purpose: The aim of this study was to determine the effects of nutritional intervention focused on a Nutrition Support Team (NST) in patients receiving enteral nutrition (EN) in general hospital wards.
권오란
core   +1 more source

Guidelines for nutrition support in the elderly [PDF]

open access: yesPublic Health Nutrition, 2001
Abstract Nutritional support in the elderly not only co-operates inpharmacological treatment but also very often is a primary therapy for their health. The type of artificial nutrition (AN) to use will depend on the present illness and the previous health
Miján de la Torre, Alberto   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

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