Results 161 to 170 of about 4,190,261 (351)

Zonated Copper‐Driven Breast Cancer Progression Countered by a Copper‐Depleting Nanoagent for Immune and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Spatially resolved multiomics reveals that high‐copper zones are closely associated with tumor metastasis, immune‐desert phenotypes, and oxidative‐phosphorylation (OXPHOS)‐dependent proliferation. A targeted bacterial nanovesicle delivering copper‐depleting agents effectively reduces tumor copper levels, inhibits OXPHOS‐dependent tumor growth, and ...
Lin Chen   +16 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

Economic feasibility of fish cage culture in Lake Victoria, Kenya

open access: yesAquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 484-492, December 2022., 2022
The study analyzed the economic viability of cage fish culture in Lake Victoria, Kenya through analysis of input‐output relationship and profitability. The study revealed that cage fish farming in the lake is profitable and worthwhile. Abstract Fish cage culture has rapidly grown throughout Lake Victoria's shores, with Nile tilapia (Oreochromis ...
Kevin Obiero   +3 more
wiley   +1 more source

THE NUTRITIONAL REQUIREMENTS OF YEAST

open access: hybrid, 1921
V. E. Nelson   +2 more
openalex   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

open access: yesAdvanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang   +10 more
wiley   +1 more source

Integration of Nile tilapia (Oreochromis niloticus) and vegetables (Amaranthus hybridus and Brassica rapa pekinensis) for improved production, water use efficiency and nutrient recycling

open access: yesAquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 493-506, December 2022., 2022
Abstract Sustainable agriculture intensification is an urgent challenge in developing countries including Tanzania. One potential solution is to adopt farming systems that increase farm production by optimizing resource use efficiency, and integrated aquaculture system, which involves farming of fish and crops, is an example of such systems. This study
Deogratias Pius Mulokozi   +4 more
wiley   +1 more source

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