Results 241 to 250 of about 3,991,247 (327)

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan, Hongyi Chen, Haolin Song, Chufeng Li, Yu Wang, Zhenhao Zhao, Qin Guo, Xuwen Li, Mingxuan Liu, Tao Sun, Chen Jiang   +10 more
wiley   +1 more source

Nutrition of Salmonella pullorum. and Salmonella Gallinarum (3) Purine Requirement of Salmonella Pullorum Strain NO.21

, 1962
Shichiro NISHIMURA
openalex   +2 more sources

Half‐Pipe Melt Electrowritten Scaffolds Support Engineering of an Immunocompetent Hydrogel‐Embedded Intestine‐on‐a‐Chip

Advanced Science, EarlyView.
The immunocompetent Intestine‐on‐a‐Chip (IoC) is developed using melt electrowritten (MEW) half‐pipes. Intestinal epithelial cell (IEC) culture is optimized in the MEW‐based IoC, followed by co‐culture with monocyte‐derived dendritic cells (moDCs) and T cells in 3D hydrogels.
Robine Janssen, Henrike S. Schulze, Claire M. L. Nelissen, Marta G. Valverde, Andrei Hrynevich, Govardus A. H. de Jong, Anne Metje van Genderen, Jos Malda, Shanna Bastiaan‐Net, Linette E. M. Willemsen, Rosalinde Masereeuw   +10 more
wiley   +1 more source

Studies on the Nutritional Requirements of Lactic Acid Bacteria in the Presence of Antibiotics. Part XII

, 1962
滋 宮沢
openalex   +2 more sources

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Spatiotemporal Transcriptomic Atlas Reveals the Regulatory Mechanisms Underlying Early Inflorescence Development and Sex Differentiation in Spinach

Advanced Science, EarlyView.
High‐resolution spatiotemporal transcriptomic data from male and female spinach inflorescences across four key stages first reveal the sex differentiation initiates at the four‐leaf stage and is governed by epigenetic regulation via the SpMSI1‐SpHDT2 complex.
Chen You, Hao Yang, Yueyan Zhao, Xiaoning Wang, Shuaijie Wei, Ning Chen, Yulan Zhang, Luxian Liu, Wei Qian, Shufen Li, Wujun Gao   +10 more
wiley   +1 more source

Nutritional Requirements of Pasteurella multocida

, 1969
Yukio Bito, Tadahide OBATA
openalex   +2 more sources

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pang   +4 more
wiley   +1 more source

Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT

Advanced Science, EarlyView.
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai, Yining Zheng, Bo Sun, Guoyan Wang, Pengfei Li, Huijun Geng, Rongnuo Li, Miaomiao Zhu, Yuanyuan Zhu, Dingping Feng, Lei Chen, Guiyan Chu, Lu Deng, Shiyan Qiao   +13 more
wiley   +1 more source