Results 271 to 280 of about 499,450 (340)

Microglia Drive Peripapillary Vascular Density Reduction in Normal Tension Glaucoma by Regulating the Rpl17/Stat5b/Apoa1 Axis

Advanced Science, EarlyView.
This study revealed that E50K mutant microglia drive retinal peripapillary vascular density reduction in NTG via the Rpl17/Stat5b/Apoa1 axis and identified Apoa1 as a novel suppressor of retinal vascular endothelial cells. These findings identify a potential therapeutic target for glaucoma and support the clinical potential of EA for protecting RGCs ...
Di Zhang, Sisi Chen, Yanfeng Zhang, Leyi Qiu, Mengxian Du, Wulian Song, Fengyi Guo, Jingyang Zhang, Xinna Liu, Huiping Yuan   +9 more
wiley   +1 more source

Nutritional Requirements for Synthesis of Heat-Labile Enterotoxin by Enterotoxigenic Strains of Escherichia coli

, 1979
Peter H. Gilligan, D C Robertson
openalex   +1 more source

OsNRT1.1B‐OsCNGC14/16‐Ca2+‐OsNLP3 Pathway: Phosphorylation‐Mediated Maintenance of Nitrogen Homeostasis

Advanced Science, EarlyView.
OsNRT1.1B forms a membrane complex with OsCNGC14/16 that mediates nitrate‐triggered calcium influx. This calcium signal phosphorylates OsNLP3 at Ser193, accelerating its nuclear translocation and activating nitrogen‐responsive genes. The calcium‐dependent pathway complements the established ubiquitination‐mediated pathway, dynamically regulating ...
Xiaohan Wang, Yongqiang Liu, Weiwei Li, Xiaojun Ma, Wei Wang, Zhimin Jiang, Yiqin Wang, Legong Li, Bin Hu, Chengcai Chu   +9 more
wiley   +1 more source

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

Advanced Science, EarlyView.
Humanized milk fat globules (MFG) mimic the native composition and structure of human milk, achieved through remodeling of milk fat globule membrane phospholipid composition and reconstruction of the tri‐layer membrane structure. These humanized MFG exhibit improved structural stability and digestibility, and enhance neurodevelopment in formula‐fed rat
Shaolei Wang, Fengzhi Qiao, Jian He, Jianxin Fu, Tongjie Liu, Huaxi Yi, Qinghai Sheng, Lanwei Zhang, Kai Lin   +8 more
wiley   +1 more source

Management of type 1 (acute) intestinal failure. [PDF]

BMJ Open Gastroenterol
Mistry P, Leach HJ, Buse ER, Smith TR.
europepmc   +1 more source

Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury

Advanced Science, EarlyView.
A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Aaron Fullerton, Victoria Marsh Durban, Riccardo Barrile, Michael A. Helmrath, Takanori Takebe, Adrian Roth, Magdalena Kasendra   +11 more
wiley   +1 more source

Study protocol for measuring energy needs and nutritional status of adolescent girls in Abia state, Nigeria: The nutrition and adolescence in rural Nigeria (NARN'ia) Study. [PDF]

PLoS One
Adegboyega MT, Amaeze CA, Uche CP, Ukegbu PO, Pontzer H.   +4 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Experiences with nutritional follow-up and barriers and opportunities of implementing digital seamless nutrition care in the head and neck cancer treatment course: a qualitative study from patient, family caregiver, and healthcare professional perspectives. [PDF]

BMC Health Serv Res
Severinsen F, Varsi C, Andersen LF, Henriksen C, Paulsen MM.   +4 more
europepmc   +1 more source