Results 41 to 50 of about 506,482 (219)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effect of Training Intervention on Nurses’ Performance in Execution of Drug and Food Delivery via Nasogastric Tube [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: The safety of a patient who receives nutritional support by tube feeding depends on nursing care and proper implementation of method and detection by the nurse in case of potential damage threatening the patient.
Milad Borji, Asma Tarjoman, Masoumeh Otaghi   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Effect of Oral Drop Gastrolit (Zataria multiflora) on Gastric Residual Volume in Mechanically Ventilated Patients Hospitalized in the Intensive Care Units

Journal of Medicinal Plants, 2018
Background: Proper nutritional support is one of the important caring aspects in patients who were hospitalized in ICU. Objective: This study was done to investigate Oral Drop Gastrolit effect on the gastric residual volume (GRV) in mechanically ...
faezeh tahershamsiAbstract: Background: Proper nutritional support is one of the important caring aspects i, korosh rezaei, sharareh khosravi, zahedin kheyri, mohammad reza memarzadeh, fatemeh rafiei   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Nutritional and metabolic assessment of critically ill children

São Paulo Medical Journal
In a prospective study, with the objective of determining the metabolic profile, response to nutrient supply, and role of nutritional and metabolic assessment parameters in children admitted to a pediatric ICU, 11 patients in the age group 2-12 were ...
Heitor Pons Leite, Werther Brunow de Carvalho, Mauro Fisberg   +2 more
doaj   +1 more source

Physical rehabilitation in patients with head and neck cancer: Impact on health‐related quality of life and suitability of a post‐treatment program

Laryngoscope Investigative Otolaryngology, 2020
Objective Physical rehabilitation programs hold the potential to mitigate deterioration in health‐related quality of life (HRQoL) in patients with head and neck cancer.
Jon Arne Sandmæl, Asta Bye, Tora S. Solheim, Trude R. Balstad, Lene Thorsen, Eva Skovlund, Stein Kaasa, Jo‐Åsmund Lund, Line Oldervoll   +8 more
doaj   +1 more source