Results 211 to 220 of about 1,727,411 (313)

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Ethnomedicinal Uses of Thai Legumes (<i>Fabaceae</i>) and Their Potential in Industrial Applications. [PDF]

Food Sci Nutr
Arshad MT, Awlqadr FH, Ullah I, Shehzadi M, Ahmad A, Ikram A, Khalid M, Hossain MS.   +7 more
europepmc   +1 more source

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Development and Feasibility of a Virtual Nutrition Education Intervention for Adults with Non-Dialysis Chronic Kidney Disease. [PDF]

Nutrients
Santos-López MF, Castro-Mata PC, García-Ramírez CC, Pérez-Galván L, Campos-Medina A, Cisneros-Hernández A, Nuño K, Chávez-Chávez HE, Diaz-Canchola LM, Cueto-Manzano AM, Martín-Del-Campo F.   +10 more
europepmc   +1 more source

Polarization Holographic 4D Phenotyping Reveals Nanoplastic Induced Dysfunction in Zooplankton

Advanced Science, EarlyView.
Contaminant‐induced dysfunction in complex aquatic organisms remains difficult to resolve across scales. Polarization Holographic Imaging Microscopy (PHIM) integrates polarization‐sensitive holography with computational volumetric reconstruction for label‐free phenotyping of zooplankton in natural seawater, revealing that nanoplastic stress drives ...
Yuxing Li, Yanmin Zhu, Jingyan Chen, Rongzhou Chen, Yuen‐Wa Ho, Chutian Wang, James Kar‐Hei Fang, Kevin K. Tsia, Edmund Y. Lam   +8 more
wiley   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source