Results 11 to 20 of about 10,687 (160)
The atypical cannabinoid O-1602 shows antitumorigenic effects in colon cancer cells and reduces tumor growth in a colitis-associated colon cancer model [PDF]
BMC Pharmacol Toxicol, 2012 Background Cannabinoids and the endocannabinoid system play an important role the protection against inflammation and cancer. O-1602, a synthetic cannabinoid with antiinflammatory properties, has little affinity to classical cannabinoid receptors but shows cannabinoid-like effects.
Kargl J +5 more
europepmc +3 more sources
Anti-Inflammatory Effects of GPR55 Agonists and Antagonists in LPS-Treated BV2 Microglial Cells [PDF]
PharmaceuticalsChronic inflammation is driven by proinflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and chemokines, such as c-c motif chemokine ligand 2 (CCL2), CCL3, C-X-C motif chemokine ligand 2 (CXCL2), and CXCL10. Inflammatory
Lu Sun +8 more
doaj +2 more sources
GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice [PDF]
Translational PsychiatryG protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in cannabinoid action and substance use disorders.
Yi He +7 more
doaj +2 more sources
Astrocytic GPR55 receptors promote glycolysis [PDF]
Journal of Cannabis ResearchBackground The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that the cannabinoid receptors CB1 and CB2 play important roles in cerebral glucose metabolism.
Cândida Dias +10 more
doaj +2 more sources
Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice [PDF]
Pancreas, 2013 The anti-inflammatory effects of O-1602 and cannabidiol (CBD), the ligands of G protein-coupled receptor 55 (GPR55), on experimental acute pancreatitis (AP) were investigated.Acute pancreatitis was induced in C57BL mice by intraperitoneal injection of 50 μg/kg cerulein hourly, with a total of 6 times.
Li, Kun +8 more
openaire +3 more sources
Activation of GPR55 Receptors Exacerbates oxLDL-Induced Lipid Accumulation and Inflammatory Responses, while Reducing Cholesterol Efflux from Human Macrophages. [PDF]
PLoS ONE, 2015 The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with bone remodelling, nervous system excitability, vascular homeostasis as well as in several pathophysiological conditions including obesity and cancer ...
Mirko Lanuti +3 more
doaj +1 more source
Anuario Lope de Vega: Texto, Literatura, Cultura, 2021 Francisco Agustín Tárrega (ca.1553-1602), el ilustre canónigo, es a un tiempo padre de la escuela dramática valenciana y contribuidor de peso en la formulación de la comedia nueva.
Clara Monzó
doaj +1 more source
Molecular Brain, 2017 The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulates anxiety and to evaluate the effectiveness ...
Qi-xin Shi +7 more
doaj +1 more source
Alguns aspectos da astrologia em Kepler
Revista Brasileira de História da Ciência, 2020 Neste trabalho apresentaremos um pequeno estudo sobre a astrologia de Kepler e algumas reflexões sobre a prática em suas concepções. O escrito que norteou nossa pesquisa foi De fundamentis astrologiae certioribus (1602), um trabalho em que temos uma ...
Luana Paula Goulart de Menezes +2 more
doaj +1 more source
Hipogrifo: Revista de Literatura y Cultura del Siglo de Oro, 2023 El género literario de los libros de caballerías castellanos (siglos XVI-XVII) conserva muchas categorías monstruosas de la literatura caballeresca medieval.
Walter José Carrizo
doaj +1 more source