Results 1 to 10 of about 3,297 (126)

Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation [PDF]

Frontiers in Molecular Neuroscience
CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GPR55 heteromers
José Arturo Avalos-Fuentes, Rodolfo Sánchez-Zavaleta, Ihosvany Rodríguez Pérez, Rafael Jijón-Lorenzo, Refugio Cruz-Trujillo, María Fernanda González de la Torre, Martha Abigail Villareal Zuñiga, Benjamín Florán   +7 more
doaj   +2 more sources

Activating GPR55 protects cochlear hair cells against cisplatin-induced ototoxicity via inhibiting MAPK pathway [PDF]

Scientific Reports
Cisplatin (CDDP) is an effective chemotherapeutic agent used to treat solid tumors, but it can cause irreversible hearing loss. Currently, there are no specific preventive measures available for this side effect.
Lingna Guo, Ruitang Wang, Yatang Wang, Houqiang Ruan, Yuhua Zhang, Yongjie Wei, Jiawei Du, Qiaojun Fang, Jianming Yang, Wei Cao   +9 more
doaj   +2 more sources

Astrocytic GPR55 receptors promote glycolysis [PDF]

Journal of Cannabis Research
Background The endocannabinoid system is closely associated with systemic and cellular energy metabolism in mammals. We previously demonstrated that the cannabinoid receptors CB1 and CB2 play important roles in cerebral glucose metabolism.
Cândida Dias, Erik Keimpema, Rui A. Carvalho, Daniela Madeira, Liliana Dias, Ana Ledo, João Laranjinha, Rodrigo A. Cunha, Paula Agostinho, Tibor Harkany, Attila Köfalvi   +10 more
doaj   +2 more sources

The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice

Neurobiology of Disease, 2022
Depression is one of the most prevalent mental illnesses in the world today, and the onset of depression is usually accompanied by neuroinflammation and impaired adult neurogenesis. As a new potential member of the endocannabinoid (eCB) system, G protein
Shifen Xu, Yuqiu Zhang, Qiuqin Han
exaly   +3 more sources

Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells. [PDF]

Vet Rec Open
Abstract Background Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype remain unclear. The endocannabinoid system (ECS) has emerged as a potential modulator of inflammation and tumour biology.
Franco GA, Marino Y, Rifici C, Fusco R, di Paola D, Cuzzocrea S, Catone G, Vullo C, Gugliandolo E.   +8 more
europepmc   +2 more sources

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study. [PDF]

Addiction
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
García-Gutiérrez MS, Torregrosa AB, Navarrete F, Aracil-Fernández A, Rubio G, Manzanares J.   +5 more
europepmc   +2 more sources

Decreased GPR55 expression links B-cell activation and vascular remodelling in atherosclerosis in patients with early rheumatoid arthritis [PDF]

RMD Open
Objective Inflammation and repair responses may be involved in atherosclerosis in rheumatoid arthritis (RA), although mechanisms are unknown. GPR55, a cannabinoid receptor expressed in haematopoietic and stromal tissues, has been implicated in ...
Javier Rodríguez-Carrio, Ana Suárez, Mercedes Alperi-López, Sara Alonso-Castro, Daniel Miranda-Prieto, Ángel I Pérez-Álvarez   +5 more
doaj   +2 more sources

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55-Mediated Signalling in Spinal Cord Injury. [PDF]

Cell Prolif
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Chen D, Liu S, Tu LY, Yang MM, Xu CW, Jiang Y, Yang H, Tai CX, Wang YN, Xie YY, Shen PP, Wang B.   +11 more
europepmc   +2 more sources

Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of rat cerebellar Purkinje cells [PDF]

eLife
Control of synaptic transmission efficacy by neuronal activity and neuromodulators is pivotal for brain function. Synaptic suppression by cannabinoids activating CB1 receptors has been extensively studied at the molecular and cellular levels to ...
Takuma Inoshita, Shin-ya Kawaguchi
doaj   +2 more sources

Cannabinoid and cannabinoid related receptors in fibroblasts, inflammatory and endothelial cells of the equine hoof with and without laminitis: novel pharmacological target [PDF]

Frontiers in Veterinary Science
BackgroundEvidence suggests that the endocannabinoid system (ECS) is crucial for regulating inflammation, cell proliferation and pain. The ECS is composed of cannabinoid receptors such as type 1 (CBR1), type 2 (CBR2) and GPR55, endocannabinoids and ...
Rodrigo Zamith Cunha, Rodrigo Zamith Cunha, Francesca Gobbo, Maria Morini, Giulia Salamanca, Giulia Salamanca, Augusta Zannoni, Chiara Bernardini, Alessandro Gramenzi, Roberto Chiocchetti   +9 more
doaj   +2 more sources