Results 31 to 40 of about 3,347 (166)

Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold

Pharmaceuticals, 2022
A growing body of evidence underlines the crucial role of GPR55 in physiological and pathological conditions. In fact, GPR55 has recently emerged as a therapeutic target for several diseases, including cancer and neurodegenerative and metabolic disorders.
Costanza Ceni, Michael J. Benko, Kawthar A. Mohamed, Giulio Poli, Miriana Di Stefano, Tiziano Tuccinardi, Maria Digiacomo, Massimo Valoti, Robert B. Laprairie, Marco Macchia, Simone Bertini   +10 more
doaj   +1 more source

What is the natural ligand of GPR55? [PDF]

Journal of Biochemistry, 2011
GPR55 is a seven transmembrane G protein-coupled receptor and was originally identified as a putative third cannabinoid receptor. Recently, lysophosphatidylinositol (LPI) was reported to be a GPR55 ligand. Stimulation of GPR55 by LPI activates G(12/13) and G(q/11) proteins, induces phosphorylation of the extracellular signal-regulated kinase and ...
Toshiaki, Okuno, Takehiko, Yokomizo
openaire   +2 more sources

GPR55-Mediated Effects in Colon Cancer Cell Lines

Medical Cannabis and Cannabinoids, 2019
The cannabinoid-responsive G protein-coupled receptor GPR55 and its endogenous ligand L-α-lysophosphatidyl­inositol (LPI) have been reported to play a role in several cancers.
Carina Hasenoehrl, David Feuersinger, Melanie Kienzl, Rudolf Schicho   +3 more
doaj   +1 more source

GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses.

PLoS ONE, 2014
G protein coupled receptor 55 (GPR55) is expressed throughout the body, and although its exact physiological function is unknown, studies have suggested a role in the cardiovascular system.
Sarah K Walsh, Emma E Hector, Anne-Christine Andréasson, Ann-Cathrine Jönsson-Rylander, Cherry L Wainwright   +4 more
doaj   +1 more source

Direct Stimulatory Effects of the CB₂ Ligand JTE 907 in Human and Mouse Islets

Cells, 2021
Aims: The endocannabinoid system is a complex cell-signaling network through which endogenous cannabinoid ligands regulate cell function by interaction with CB1 and CB2 cannabinoid receptors, and with the novel cannabinoid receptor GPR55.
Inmaculada Ruz-Maldonado, Patricio Atanes, Guo Cai Huang, Bo Liu, Shanta J Persaud   +4 more
doaj   +1 more source

Cannabinoid receptors in the inflammatory cells of canine atopic dermatitis

Frontiers in Veterinary Science, 2022
BackgroundAtopic dermatitis (AD) is one of the most common cutaneous inflammatory and pruritic diseases in dogs. Considering its multifactorial nature, AD can be a challenging disease to manage, and the therapeutic strategy must often be multimodal.
Roberto Chiocchetti, Giulia Salamanca, Margherita De Silva, Francesca Gobbo, Francesca Aspidi, Rodrigo Zamith Cunha, Giorgia Galiazzo, Claudio Tagliavia, Claudio Tagliavia, Giuseppe Sarli, Maria Morini   +10 more
doaj   +1 more source

High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain [PDF]

PeerJ, 2020
Background The insulin-sensitizing phytocannabinoid, Δ(9)-tetrahydrocannabivarin (THCV) can signal partly via G-protein coupled receptor-55 (GPR55 behaving as either an agonist or an antagonist depending on the assay).
Edward T. Wargent, Malgorzata Kepczynska, Mohamed Sghaier Zaibi, David C. Hislop, Jonathan R.S. Arch, Claire J. Stocker   +5 more
doaj   +2 more sources

A potential role for GPR55 in gastrointestinal functions

Current Opinion in Pharmacology, 2012
Despite sharing little homology (10-15%) with cannabinoid-1 (CB(1)) and cannabinoid-2 (CB(2)) receptors, the G protein-coupled receptor 55 (GPR55) was initially thought to be a new member of the cannabinoid receptor family. Apart from being activated by various exogenous cannabinoids, GPR55 is also activated by endocannabinoids like anandamide, which ...
Schicho, Rudolf, Storr, Martin
openaire   +2 more sources

Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands [PDF]

Biochemistry, 2011
Marijuana is the most widely abused illegal drug, and its spectrum of effects suggests that several receptors are responsible for the activity. Two cannabinoid receptor subtypes, CB1 and CB2, have been identified, but the complex pharmacological properties of exogenous cannabinoids and endocannabinoids are not fully explained by their signaling.
Evangelia, Kotsikorou, Karla E, Madrigal, Dow P, Hurst, Haleli, Sharir, Diane L, Lynch, Susanne, Heynen-Genel, Loribelle B, Milan, Thomas D Y, Chung, Herbert H, Seltzman, Yushi, Bai, Marc G, Caron, Larry, Barak, Mary E, Abood, Patricia H, Reggio   +13 more
openaire   +2 more sources

Identification of the GPR55 Antagonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands [PDF]

Biochemistry, 2013
GPR55 is a class A G protein-coupled receptor (GPCR) that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and cancer. Initially deorphanized as a cannabinoid receptor, GPR55 has been shown to be activated by non-cannabinoid ligands such as l-α-lysophosphatidylinositol (LPI).
Evangelia, Kotsikorou, Haleli, Sharir, Derek M, Shore, Dow P, Hurst, Diane L, Lynch, Karla E, Madrigal, Susanne, Heynen-Genel, Loribelle B, Milan, Thomas D Y, Chung, Herbert H, Seltzman, Yushi, Bai, Marc G, Caron, Larry S, Barak, Mitchell P, Croatt, Mary E, Abood, Patricia H, Reggio   +15 more
openaire   +2 more sources