Results 21 to 30 of about 3,347 (166)
Receptors for acylethanolamides—GPR55 and GPR119 [PDF]
Prostaglandins & Other Lipid Mediators, 2009 Acylethanolamides are lipid substances widely distributed in the body, generated from a membrane phospholipid precursor, N-acylphosphatidylethanolamine (NAPE). The recent identification of arachidonoyl ethanolamide (anandamide or AEA) as an endogenous cannabinoid ligand has focused attention on acylethanolamides, which has further increased with the ...
Grzegorz, Godlewski +3 more
openaire +2 more sources
GPR55: Metabolic Help or Hindrance? [PDF]
Trends in Endocrinology & Metabolism, 2016 Since the discovery of the lysophospholipid-sensitive receptor GPR55, hopes have been raised that targeting this G protein-coupled receptor (GPCR) may represent a novel approach for the treatment of metabolic disorders. We discuss conflicting evidence surrounding GPR55 physiology and highlight its potential as a novel target for the treatment of ...
Henstridge, Christopher +2 more
openaire +4 more sources
GPR55 and the vascular receptors for cannabinoids [PDF]
British Journal of Pharmacology, 2007 CB1 and CB2 receptors mediate most responses to cannabinoids but not some of the cardiovascular actions of endocannabinoids such as anandamide and virodhamine, or those of some synthetic agents, like abnormal cannabidiol (abn‐cbd). These agents induce vasorelaxation which is antagonised by rimonabant but only at high concentrations relative to those ...
C R, Hiley, S S, Kaup
openaire +2 more sources
Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin
npj Science of Food, 2022 The identification of molecular targets of bioactive food components is important to understand the mechanistic aspect of their physiological functions.
Naoki Harada +16 more
doaj +1 more source
Rod photoreceptors express GPR55 in the adult vervet monkey retina. [PDF]
PLoS ONE, 2013 Cannabinoids exert their actions mainly through two receptors, the cannabinoid CB1 receptor (CB1R) and cannabinoid CB2 receptor (CB2R). In recent years, the G-protein coupled receptor 55 (GPR55) was suggested as a cannabinoid receptor based on its ...
Joseph Bouskila +4 more
doaj +1 more source
Cells, 2023 GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has been described to show accelerating and decelerating effects in tumor progression resulting from distinct intracellular signaling pathways.
Marc Richard Kolbe +8 more
doaj +1 more source
The oncogenic lysophosphatidylinositol (LPI)/GPR55 signaling
Life Sciences, 2022 GPR55 is a class A orphan G protein-coupled receptor that has drawn important therapeutic attention in the last decade because of its role in pathophysiological processes including vascular functions, metabolic dysfunction, neurodegenerative disorders, or bone turnover among others.
Calvillo-Robledo, Argelia +3 more
openaire +3 more sources
Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages
Scientific Reports, 2023 Atherosclerosis is a major cause of cerebral and cardiovascular diseases. Intravascular plaques, a well-known pathological finding of atherosclerosis, have a necrotic core composed of macrophages and dead cells.
Ryosuke Shimai +11 more
doaj +1 more source
Biology, 2023 Background: The endocannabinoid system (ECS) and associated lipid transmitter-based signaling systems play an important role in modulating brain neuroinflammation. ECS is affected in neurodegenerative disorders, such as Alzheimer’s disease (AD).
Dina Medina-Vera +8 more
doaj +1 more source
GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats
Pharmaceuticals, 2022 Orphan G-protein-coupled receptors (GPCR) comprise a large number of receptors which are widely distributed in the nervous system and represent an opportunity to identify new molecular targets in pain medicine.
Ángel Zúñiga-Romero +8 more
doaj +1 more source