GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis [PDF]
Frontiers in ImmunologyBackgroundThe G protein-coupled receptor 55 (GPR55) is part of an expanded endocannabinoid system (ECS), and plays a pro-tumorigenic role in different cancer models, including pancreatic cancer.
Dušica Ristić +8 more
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Ginseng Gintonin Contains Ligands for GPR40 and GPR55 [PDF]
Molecules, 2020 Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including
Yeon-Jin Cho +9 more
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Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55 [PDF]
Nature CommunicationsGPR55 is an orphan G protein-coupled receptor (GPCR) and represents a promising drug target for cancer, inflammation, and metabolic diseases. The endogenous activation of lipid GPCRs can be solely mediated by membrane components and different lipids have
Tobias Claff +5 more
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The Therapeutic Potential of Orphan GPCRs, GPR35 and GPR55 [PDF]
Frontiers in Pharmacology, 2015 The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family of signal transducers, comprised of ~1000 members. Considering their prevalence and functional importance, it’s not surprising that ~60% of drugs target GPCRs ...
Patricia Hodapp Reggio, Derek M Shore
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PLoS ONE, 2023 A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet syndrome.
Lyndsey L. Anderson +6 more
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Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning
Cell Communication and Signaling, 2021 Background The G-protein-coupled receptor GPR55 has been implicated in multiple biological activities, which has fuelled interest in its functional targeting.
Maria Giovanna Mosca +4 more
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Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells. [PDF]
PLoS ONE, 2011 GPR55 was recently identified as a putative receptor for certain cannabinoids, and lysophosphatidylinositol (LPI). Recently, the role of cannabinoids as GPR55 agonists has been disputed by a number of reports, in part, because studies investigating GPR55
Yutaro Obara +3 more
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Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling
Scientific Reports, 2021 While classical cannabinoid receptors are known to crucially impact on myocardial infarction (MI) repair, a function of the cannabinoid-sensitive receptor GPR55 herein is poorly understood. We investigated the role of GPR55 in cardiac physiology and post-
Sarah-Lena Puhl +8 more
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Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation. [PDF]
PLoS ONE, 2016 The G-protein coupled receptor 55 (GPR55) is activated by cannabinoids and non-cannabinoid molecules and has been speculated to play a modulatory role in a large variety of physiological and pathological processes, including in metabolically perturbed ...
Mikael Bjursell +5 more
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GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. [PDF]
PLoS ONE, 2013 The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology.
Chia-Shan Wu +10 more
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