Results 51 to 60 of about 16,307,918 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity

Vaccines, 2021
Self-assembling protein nanoparticles (SAPN) serve as a repetitive antigen delivery platform with high-density epitope display; however, antigen characteristics such as size and epitope presentation can influence the immunogenicity of the assembled ...
Cosette G. Schneider, Justin A. Taylor, Michael Q. Sibilo, Kazutoyo Miura, Katherine L. Mallory, Christopher Mann, Christopher Karch, Zoltan Beck, Gary R. Matyas, Carole A. Long, Elke Bergmann-Leitner, Peter Burkhard, Evelina Angov   +12 more
doaj   +1 more source

Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]

, 2010
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M., Robinson, B.W.S., Currie, A.J.   +2 more
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation [PDF]

, 2019
Two Shigella species, flexneri and sonnei, cause approximately 90% of bacterial dysentery worldwide. While S. flexneri is the dominant species in low-income countries, S. sonnei causes the majority of infections in middle and high-income countries.
Goddard, Philippa J., Shenoy, Avinash R., Abigail Clements, Shenoy, Avinash R, Serge Mostowy, Mostowy, Serge, Philippa J. Goddard, Goddard, Philippa J, Torraca, V., Watson, Jayne, Clements, Abigail, Jayne L. Watson, Avinash R. Shenoy, Watson, Jayne L., Torraca, Vincenzo, Shenoy, Avinash, Julia Sanchez-Garrido, Sanchez-garrido, Julia, Goddard, Philippa, Watson, Jayne L, Vincenzo Torraca   +20 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Variation of the O antigen of Campylobacter jejuni in vivo [PDF]

Journal of Medical Microbiology, 1992
During the course of a clinical study on patients with campylobacteriosis, three consecutive isolates of Campylobacter jejuni from the same patient were sent for O-serotyping. Marked differences in the specificities of the O antigens of the isolates were observed between the first and third isolates when a passive haemagglutination assay system ...
S D, Mills, B, Kuzniar, B, Shames, L A, Kurjanczyk, J L, Penner   +4 more
openaire   +2 more sources

Antigen-Drug Conjugates as a Novel Therapeutic Class for the Treatment of Antigen-Specific Autoimmune Disorders [PDF]

, 2019
Multiple sclerosis represents the world’s most common cause of neurological disability in young people and is attributed to a loss of immune tolerance toward proteins of the myelin sheath.
Sharadvi Thati, Sharadvi Thati (6240698), Pickens, Chad J., Martin A. Leon (6658805), Pressnall, Melissa M., Thati, Sharadvi, Cory Berkland (1399867), Berkland, Cory, Melissa M. Pressnall (6240704), Stephanie N. Johnson (4743330), Chad J. Pickens (4031816), Christopher, Matthew A., Johnson, Stephanie N., Sullivan, Bradley P., Matthew A. Christopher (6240695), Leon, Martin A., Martin A. Leon, Bradley P. Sullivan, Cory Berkland, Melissa M. Pressnall, Stephanie N. Johnson, Chad J. Pickens, Bradley P. Sullivan (1558699), Matthew A. Christopher   +23 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source