Results 41 to 50 of about 15,473,053 (283)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Exploring Y1 Communications and Services in O-RAN: Background, Privacy, and Security

IEEE Open Journal of the Communications Society
In the latest open radio access network (O-RAN) architecture, the Y1 interface has been introduced to grant authorized parties, known as Y1 consumers, access to and utilization of Y1 data within the near-real-time RAN intelligent controller (Near-RT RIC).
Sachinkumar B. Mallikarjun, Mohammad Asif Habibi, Mihirraj Dixit, Xavier Costa-Perez, Merouane Debbah, Hans D. Schotten   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Empowering Next-Gen Networks: AI-Driven Autonomy in O-RAN and SON Architectures

IEEE Access
Wireless communication plays a crucial role in evolving next-generation networks. Open Radio Access Networks (O-RAN), Self-Organizing Networks (SON), and Artificial Intelligence (AI)-driven automation are set to revolutionize network operations by ...
Dalia Abouelmaati, Alireza Esfahani, Shidrokh Goudarzi, Shahid Mumtaz   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Intelligent Control in 6G Open RAN: Security Risk or Opportunity?

IEEE Open Journal of the Communications Society
The Open Radio Access Network (Open RAN) framework, emerging as the cornerstone for Artificial Intelligence (AI)-enabled Sixth-Generation (6G) mobile networks, heralds a transformative shift in radio access network architecture.
Sanaz Soltani, Ali Amanloo, Mohammad Shojafar, Rahim Tafazolli   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

SEM-O-RAN: Semantic O-RAN Slicing for Mobile Edge Offloading of Computer Vision Tasks

IEEE Transactions on Mobile Computing
The next generation of mobile networks (NextG) will require careful resource management to support edge offloading of resource-intensive deep learning (DL) tasks. Current slicing frameworks treat all DL tasks equally without adjusting to their high-level objectives, resulting in sub-optimal performance.
Corrado Puligheddu, Jonathan D. Ashdown, Carla-Fabiana Chiasserini, Francesco Restuccia 0001   +3 more
openaire   +3 more sources