o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2 [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryToll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions.
Md. Habibur Rahaman +16 more
doaj +8 more sources
o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells [PDF]
Cells, 2022 Human mesenchymal stem cell (hMSC) and extracellular vesicle (EV) therapy is a promising treatment for discogenic low back pain (LBP). Although promising, major obstacles remain to be overcome.
Li Li +5 more
doaj +3 more sources
O-Vanillin Attenuates the TLR2 Mediated Tumor-Promoting Phenotype of Microglia. [PDF]
Int J Mol Sci, 2020 Malignant gliomas are primary brain tumors with poor prognoses. These tumors are infiltrated by brain intrinsic microglia and peripheral monocytes which promote glioma cell invasion. In our previous studies, we discovered that the activation of Toll-like
Triller P +4 more
europepmc +6 more sources
Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro. [PDF]
J Clin Med, 2019 Curcumin and o-Vanillin cleared senescent intervertebral disc (IVD) cells and reduced the senescence-associated secretory phenotype (SASP) associated with inflammation and back pain. Cells from degenerate and non-mildly-degenerate human IVD were obtained
Cherif H +5 more
europepmc +5 more sources
Toll-like receptor 2 induced senescence in intervertebral disc cells of patients with back pain can be attenuated by o-vanillin. [PDF]
Arthritis Res Ther, 2021 Background There is an increased level of senescent cells and toll-like teceptor-1, -2, -4, and -6 (TLR) expression in degenerating intervertebral discs (IVDs) from back pain patients.
Mannarino M +8 more
europepmc +2 more sources
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway. [PDF]
Sci Rep, 2021 Schiff base compounds and their metal complexes have become important synthetic organic drugs due to their extensive biological activities, which include anticancer, antibacterial and antiviral effects.
Li H +6 more
europepmc +2 more sources
1D AND 2D NMR STUDIES OF BENZYL O–VANILLIN
Indonesian Journal of Chemistry, 2010 The reaction of o-vanillin A with benzyl bromide B2 in acetone as the solvent and K2CO3 as a base in the presence of tetra-n-butylammonium iodide (TBAI) as catalyst formed benzyl o-vanillin, C.
Mohammed Hadi Al–Douh +2 more
doaj +4 more sources
UV/Vis spectroelectrochemistry of o-vanillin: Study of the antioxidant properties [PDF]
Journal of Electroanalytical Chemistry, 2020 UV/Vis absorption spectroelectrochemistry is a very useful technique to study complex electrochemical mechanisms. In this work, we have studied the electrochemistry of o-vanillin in presence and absence of oxygen.
A. C. González-Baró +3 more
semanticscholar +5 more sources
Synthesis and biological evaluation of ibuprofen/o-vanillin Schiff base complexes with anti-inflammatory, anti-proliferative and anti-SARS-COV-19 activities [PDF]
Scientific ReportsThis study presents the synthesis and comprehensive characterization of four novel metal-complexes formed from the reaction of copper(II), nickel(II), zinc(II), and vanadium(IV) salts with the bidentate ibuprofen Schiff base ligand (HL) in 1:1 metal-to ...
Laila H. Abdel-Rahman +6 more
doaj +2 more sources
2-Hydroxy-3-methoxybenzaldehyde (o-vanillin) revisited [PDF]
Acta Crystallographica Section E, 2012 The structure of ortho-vanillin, C8H8O3, has been revisited with modern methods and at low temperature (100 K). The previous structure [Iwasaki et al. (1976). Acta Cryst.
David Shin, Peter Müller
doaj +5 more sources