Nature Communications, 2020 The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies ...
C. Coral Domínguez-Medina +23 more
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Questioning universal use of O– red blood cells in intrauterine transfusions
AJOG Global Reports, 2023 In the setting of maternal alloimmunization to antigen(s) on fetal red blood cells, significant fetal anemia may develop, and an intrauterine transfusion may be required. When selecting a blood product for intrauterine transfusion, the priority should be
Olivia G. Johnson, BS +1 more
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To respond or not to respond - a personal perspective of intestinal tolerance [PDF]
, 2018 For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka +142 more
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Parasites & Vectors, 2019 Background New candidate protective antigens for tick vaccine development may be identified by selecting and testing antigen candidates that play key biological functions.
Ricardo Pérez-Sánchez +3 more
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The identification of novel immunogenic antigens as potential Shigella vaccine components
Genome Medicine, 2021 Background Shigella is a major diarrheal pathogen for which there is presently no vaccine. Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines.
Ruklanthi de Alwis +9 more
doaj +1 more source
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
, 1989 Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
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Identification of the lipopolysaccharide O‐antigen biosynthesis priming enzyme and the O‐antigen ligase in Myxococcus xanthus: critical role of LPS O‐antigen in motility and development [PDF]
Molecular Microbiology, 2019 SummaryMyxococcus xanthus is a model bacterium to study social behavior. At the cellular level, the different social behaviors of M. xanthus involve extensive cell–cell contacts. Here, we used bioinformatics, genetics, heterologous expression and biochemical experiments to identify and characterize the key enzymes in M.
María Pérez‐Burgos +4 more
openaire +4 more sources
Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]
, 2014 Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh +9 more
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Development of a Potent Stabilizer for Long-Term Storage of Foot-and-Mouth Disease Vaccine Antigens
Vaccines, 2021 A local virus isolate, O/SKR/JC/2014 (O JC), has been considered as a candidate vaccine strain in the development of a domestic foot-and-mouth disease (FMD) vaccine in Korea.
Ah-Young Kim +7 more
doaj +1 more source
Validation of a Polymerase Chain Reaction technique for Kidd blood group genotyping [PDF]
, 2015 The Kidd blood group antigens, Jkª and Jkᵇ , are two of the main surface markers which are found on the membrane of red blood cells. The determination of whether a donor or a recipient has the Jkª and/or the Jkᵇ antigens is crucially important to ...
Borg, Joseph J. +2 more
core +1 more source