Results 1 to 10 of about 940,991 (254)

Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells

Cancer & Metabolism, 2021
Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver malignancy and carries poor prognoses due to late presentation of symptoms.
Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman, P. Darrell Neufer   +8 more
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The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Nature Communications, 2021
Chlorpyrifos is a widely-used pesticide and a common residue on vegetables and fruits. Here the authors show that at non-neurotoxic doses, chlorpyrifos reduces energy expenditure, by inhibiting diet induced thermogenesis, and promotes obesity and insulin
Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, Andrea Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E. Green, Emily A. Day, Brennan K. Smith, James S. V. Lally, Jianhan Wu, Amogelang R. Raphenya, Krishna A. Srinivasan, Andrew G. McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg   +19 more
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Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto’s thyroiditis: a case report

Journal of Medical Case Reports, 2022
Background Latent autoimmune diabetes in adults is an infrequent form of autoimmune diabetes mellitus, while Hashimoto’s thyroiditis, the most common thyroid disease in adults, rarely manifests as thyrotoxicosis.
Maria Xenou, Ioannis Zoupas, Dimitrios Lygnos, Evangelos Fousteris   +3 more
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Association between hepatic steatosis and fibrosis with measures of insulin sensitivity in patients with severe obesity and type 2 diabetes - a cross-sectional study

BMC Gastroenterology, 2022
Background Obesity, non-alcoholic fatty liver disease (NAFLD) and insulin resistance are three pathological conditions highly correlated, but this relationship is not fully elucidated.
Kathrine Aglen Seeberg, Dag Hofsø, Heidi Borgeraas, John Olav Grimnes, Farhat Fatima, Lars Thomas Seeberg, Nils Petter Kvan, Marius Svanevik, Jens Kristoffer Hertel, Jøran Hjelmesæth   +9 more
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Obesity [PDF]

The Lancet, 2005
Excess bodyweight is the sixth most important risk factor contributing to the overall burden of disease worldwide. 1.1 billion adults and 10% of children are now classified as overweight or obese. Average life expectancy is already diminished; the main adverse consequences are cardiovascular disease, type 2 diabetes, and several cancers.
David W, Haslam, W Philip T, James
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Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes

Stem Cells International, 2022
Mitochondrial dysfunction in white adipose tissue is strongly associated with obesity and its metabolic complications, which are important health challenges worldwide.
Elena Herbers, Mimmi Patrikoski, Anita Wagner, Riikka Jokinen, Antti Hassinen, Sini Heinonen, Susanna Miettinen, Hilkka Peltoniemi, Eija Pirinen, Kirsi H. Pietiläinen   +9 more
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CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading

Journal of Translational Medicine, 2018
Background Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progression from simple
Xin Chu, Qunyan Jin, Hui Chen, G. Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J. Carey, Christopher D. Still, Johanna K. DiStefano, Glenn S. Gerhard   +12 more
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Strengthening resistance to the COVID-19 pandemic and fostering future resilience requires concerted action on obesity

Global Health Action, 2020
Initial observations showed that people with chronic noncommunicable diseases were at heightened risk of severe COVID-19 and adverse outcomes. Subsequently, data from various countries have revealed obesity as an independent and significant factor, with ...
Angela M. Jackson-Morris, Rachel Nugent, Johanna Ralston, Olivia Barata Cavalcanti, John Wilding   +4 more
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Gender-related differences in cardiometabolic risk factors and lifestyle behaviors in treatment-seeking adolescents with severe obesity

BMC Pediatrics, 2018
Background Obesity during adolescence is associated with cardiovascular mortality in adulthood. The adverse obesity-related cardiometabolic risk profile is already observed in adolescence.
Lisa Ha Barstad, Pétur B. Júlíusson, Line Kristin Johnson, Jens Kristoffer Hertel, Samira Lekhal, Jøran Hjelmesæth   +5 more
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The CMDO Network's Health Research and AI symposium

McGill Journal of Medicine, 2023
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Cardiometabolic Health, Diabetes and obesity Research Network
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