Results 31 to 40 of about 1,339,496 (303)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Physical activity and sleep changes among children during the COVID-19 pandemic

npj Digital Medicine
Daily routines, including in-person school and extracurricular activities, are important for maintaining healthy physical activity and sleep habits in children.
Karnika Singh, Sarah C. Armstrong, Brooke E. Wagner, Julie Counts, Asheley Skinner, Melissa Kay, Jennifer S. Li, Svati Shah, Nancy Zucker, Cody Neshteruk, Mary Story, Lilianna Suarez, William E. Kraus, Alexandra R. Zizzi, Jessilyn Dunn   +14 more
doaj   +1 more source

Distorted chemosensory perception and female sex associate with persistent smell and/or taste loss in people with SARS-CoV-2 antibodies: a community based cohort study investigating clinical course and resolution of acute smell and/or taste loss in people with and without SARS-CoV-2 antibodies in London, UK

BMC Infectious Diseases, 2021
Background Loss of smell and/or taste are cardinal symptoms of COVID-19. ‘Long-COVID’, persistence of symptoms, affects around one fifth of people. However, data regarding the clinical resolution of loss of smell and/or taste are lacking.
Janine Makaronidis, Chloe Firman, Cormac G. Magee, Jessica Mok, Nyaladzi Balogun, Matt Lechner, Alisia Carnemolla, Rachel L. Batterham   +7 more
doaj   +1 more source

Change in liver stiffness at 12 months using two-dimensional shear wave elastography in individuals with class 3 obesity

, 2023
Background: Metabolic-associated fatty liver disease (MAFLD) is common among patients with class 3 obesity, and weight loss may result in reduction in this stiffness.
Kormas, Nick, Ho, Vincent (R16852), Grudzinskas, Kathy, Piya, Milan K. (R19111), Chimoriya, Ritesh (R20404), Acosta Reyes, Pamela (S37563)   +5 more
core  

Fat Mass and Obesity-Associated Gene (FTO) in Eating Disorders: Evidence for Association of the rs9939609 Obesity Risk Allele with Bulimia nervosa and Anorexia nervosa [PDF]

, 2012
Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating ...
Wichmann, Heinz-Erich, Herzog, Wolfgang, Estivill, X., Fichter, Manfred, Sorbi, S., Ribasés Haro, Marta, Herpertz-Dahlmann, B., Hebebrand, J., Ehrlich, Stefan, Greene, B. H., Müller, Timo D., Estivill, Xavier, Fernandez-Aranda, Fernando, Scherag, Susan, Cavallini, M. C., Hebebrand, Johannes, Schäfer, Helmut, Ribases, Marta, Sorbi, Sandro, Herpertz Dahlmann, Beate, Lehmkuhl, Ulrike, Grallert, Harald, Fleischhaker, C., Wichmann, H.-E., Illig, T., Bellodi, L., Herzog, W., Fichter, M., Cellini, E., Bellodi, Laura, Ricca, Valdo, Fleischhaker, Christian, Scherag, Susann, Di Bella, D., Bella, Daniela Di, Cavallini, M.C., Scherag, S., Nacmias, Benedetta, Greene, B.H., Illig, Thomas, Schäfer, H., Fernández Aranda, Fernando, Fernández-Aranda, F., Di Bella, Daniela, Gratacòs, Monica, Erzegovesi, S., Cellini, Elena, Scherag, Andre, Fichter, Manfred M., Greene, Brandon H., Müller, T. D., Grallert, H., Nacmias, B., Hinney, A., Hinney, Anke, Erzegovesi, Stefano, Ribasés, M., Scherag, A., Wichmann, H. E., Müller, T.D., Cavallini, Maria C., Herpertz-Dahlmann, Beate, Estivill, Xavier, 1955-, Gratacòs, M., Ricca, V., Ehrlich, S., Lehmkuhl, U., Wichmann, H.-Erich   +67 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Women with class 3 obesity with and without polycystic ovarian syndrome : outcomes from a multidisciplinary weight management program

, 2023
Background/Aims: Polycystic ovarian syndrome (PCOS) may affect outcomes following a weight management program (WMP). This study aimed to assess the prevalence of PCOS in women with class 3 obesity joining a multidisciplinary WMP, and compare 12-month ...
Bueno, Flavia, Grudzinskas, Kathy, Kormas, Nic, Piya, Milan K. (R19111), Gialouris, Joshua V., Chimoriya, Ritesh (R20404), Acosta Reyes, Pamela (S37563)   +6 more
core  

Is BMI alone a sufficient outcome to evaluate interventions for child obesity? [PDF]

, 2013
BACKGROUND: BMI is often used to evaluate the effectiveness of childhood obesity interventions, but such interventions may have additional benefits independent of effects on adiposity.
Kapetanakis, V, Kolotourou, M, Singhal, Atul, Kapetanakis, Venediktos, Cole, Tim J., Singhal, A, Smith, Lindsey, Orfanos, Stravos, Chadwick, Paul, Chadwick, P, Sacher, Paul M., Orfanos, S, Kolotourou, Maria, Radley, Duncan, Radley, D, Smith, L, Cole, TJ, Sacher, PM, Orfanos, Stavros   +18 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Evaluation of the scale-up and implementation of mind, exercise, nutrition … do it! (MEND) in British Columbia: a hybrid trial type 3 evaluation

BMC Pediatrics, 2020
Background The Mind, Exercise, Nutrition … Do it! (MEND) childhood obesity intervention was implemented in British Columbia (B.C.), Canada from April 2013 to June 2017.
Sam Liu, Joy Weismiller, Karen Strange, Lisa Forster-Coull, Jennifer Bradbury, Tom Warshawski, Patti-Jean Naylor   +6 more
doaj   +1 more source