Results 61 to 70 of about 184,113 (304)

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

The Hazards of Abdominal Obesity [PDF]

International Journal of Global Health, 2020
Abdominal obesitywith a big belly is one of the worse type of morbid obesity that is associated with different health failure outcomes. Central obesity leads to an increased risk of health complications such as metabolic syndrome, hypertension, insulin resistance,type 2 diabetes, heart disease and various cancers.
openaire   +1 more source

Waist circumference as a determinant of hypertension and diabetes in Brazilian women: a population-based study. [PDF]

, 2004
OBJECTIVE: To evaluate the role of central adiposity, as evaluated by the measurement of waist circumference (WC), as an independent risk factor for hypertension and type 2 diabetes mellitus in the setting of a developing country.
Nacul, LC, Macedo, S, Olinto, MTA, Costa, JSD, Gigante, DP, Menezes, AMB   +5 more
core   +1 more source

Primary Tumor Resection in Patients With Unresectable Metastatic Colorectal Cancer: A Systematic Review and Meta‐Analysis

Annals of Gastroenterological Surgery, EarlyView.
This systematic review and meta‐analysis evaluated the role of primary tumor resection (PTR) in asymptomatic patients with unresectable metastatic colorectal cancer. Across 17 eligible studies including 9317 patients, PTR did not improve overall or progression‐free survival compared with chemotherapy alone.
Junpei Takashima, Hirotoshi Kobayashi, Daisuke Fujimoto, Fumihiko Miura   +3 more
wiley   +1 more source

Short‐Term Outcomes of Robot‐Assisted Versus Laparoscopic Colectomy for Colon Cancer: A Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
This study compared short‐term outcomes of robot‐assisted versus laparoscopic colectomy for colon cancer using 1:1 propensity score matching. Among 218 matched pairs, robot‐assisted colectomy was associated with reduced blood loss, fewer conversions to open surgery, lower overall complication rates, and shorter hospital stays, despite longer operative ...
Akira Inoue, Yujiro Nishizawa, Yoshinori Kagawa, Masahiro Hashimoto, Shinya Kato, Yoshihiro Morimoto, Taishi Hata, Makoto Fujii, Masaaki Motoori, Kazumasa Fujitani   +9 more
wiley   +1 more source

Television viewing time and risk of incident obesity and central obesity: the English longitudinal study of ageing

, 2015
Background Research suggests television viewing time may be associated with incident obesity and central obesity in young adults. No study has investigated these associations in older English adults.
Fisher, A, Lee Smith, Abigail Fisher, Mark Hamer, Smith, L, Hamer, M   +5 more
core   +1 more source

Vascular Abnormalities in Hypermobile Ehlers–Danlos Syndrome: A Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Hypermobile Ehlers–Danlos syndrome (hEDS), while generally free from severe vascular complications, may occasionally present with cardiac and vascular abnormalities that warrant specific investigation. While studies have been conducted on the prevalence of cardiac involvement, none have focused on vascular aspects. This retrospective study was
Thomas Gehin, Malika Foy, Robert Carlier, Valentin Renault, Karelle Benistan   +4 more
wiley   +1 more source

Effect of abdominal obesity on insulin resistance and the components of the metabolic syndrome: Evidence supporting obesity as the central feature

, 2003
Background: Metabolic syndrome includes abdominal obesity, diabetes type 2, hypertension, dyslipidemia, derangements of fibrinolysis, and atherosclerosis. Since abdominal obesity is one of the major components of the insulin resistance syndrome (IRS), an
Ozcan, Rahşan, Buyukdevrim, AS, Gunay, D, Duman, BS, Turkoglu, Cengizhan, Cagatay, PENBE   +5 more
core   +2 more sources

Association between Abdominal Obesity and Cardiovascular Risk Factors in Adults with Normal Body Mass Index: Based on the Sixth Korea National Health and Nutrition Examination Survey

Journal of Obesity & Metabolic Syndrome, 2019
Background : Abdominal obesity predisposes individuals to cardiovascular disease, but the data in adults with normal body mass index (BMI) are relatively rare.
Hye Yun Kim, Jae Kyung Kim, Gook Gyeon Shin, Jin Ah Han, Jin Wook Kim   +4 more
doaj   +1 more source