Results 11 to 20 of about 2,007,139 (344)

Genetic studies of body mass index yield new insights for obesity biology

Nature, 2015
Adam E Locke, Bratati Kahali, Anne E Justice   +2 more
exaly   +2 more sources

Tirzepatide Once Weekly for the Treatment of Obesity.

New England Journal of Medicine, 2022
BACKGROUND Obesity is a chronic disease that results in substantial global morbidity and mortality. The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, in people with ...
W. Garvey, J. Frias, Ania M Jastreboff, C. Roux, N. Sattar, D. Aizenberg, H. Mao, Shuyu Zhang, N. Ahmad, M. Bunck, I. Benabbad, Xiaotian M Zhang, Franklin H. Abalos, F. P. Manghi, C. Zaidman, Marisa L. Vico, P. Costanzo, L. Serra, I. Mackinnon, M. Hissa, M. Vidotti, J. Saraiva, B. Alves, D. Franco, Otavio Moratto, S. Murthy, Ghanshyam Goyal, Y. Yamasaki, Nobuyuki Sato, S. Inoue, Taro Asakura, M. Shestakova, E. Khaykina, E. Troshina, N. Vorokhobina, A. Ametov, S. Tu, Chwen-Yi Yang, I. Lee, Chien-Ning Huang, H. Ou, George Freeman, S. Machineni, K. Klein, Senan Sultan, A. Parsa, Juan Otero-Martinez, Alexy González, A. Bhargava, S. Brian, Carlos Ince, S. Plantholt, J. Cole, A. Lacour, D. Vega, José Deivison de Souza, Jane L. Rohlf, Roy C. St. John, Barry S. Horowitz, Hanid Audish, Rodolfo J. Galindo, Guillermo Umpiperrez, J. Ard, Brian Curtis, W. Garvey, Neil J. Fraser, J. Mandry, R. Mohseni, R. Mayfield, Talessa Powell, Carl Vance, Stephen Ong, Ana L. Lewy-Alterbaum, Alexander Murray, Amer Al-Karadsheh, Tamer G. Yacoub, K. Roberts, David L. Fried, J. Rosenstock, Bharathi Pulla, B. Bode, J. Frias, L. Klaff, R. Brazg, J. Van, Anjanette S. Tan, Toby Briskin, M. Rhee, Tira Chaicha-Brom, P. Hartley, L. Nunez, Gregorio Cortes-Maisonet, G. Soucie, S. Hsia, Thomas C. Jones   +94 more
semanticscholar   +1 more source

Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association

Circulation, 2021
The global obesity epidemic is well established, with increases in obesity prevalence for most countries since the 1980s. Obesity contributes directly to incident cardiovascular risk factors, including dyslipidemia, type 2 diabetes, hypertension, and ...
Tiffany Powell-wiley, P. Poirier, L. Burke, J. Despres, P. Gordon-Larsen, C. Lavie, S. Lear, C. Ndumele, I. Neeland, P. Sanders, M. St-Onge   +10 more
semanticscholar   +1 more source

Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells

Cancer & Metabolism, 2021
Background Hepatocellular carcinoma (HCC) is the most prevalent form of liver malignancy and carries poor prognoses due to late presentation of symptoms.
Cameron A. Schmidt, Kelsey L. McLaughlin, Ilya N. Boykov, Rafiq Mojalagbe, Arthi Ranganathan, Katherine A. Buddo, Chien-Te Lin, Kelsey H. Fisher-Wellman, P. Darrell Neufer   +8 more
doaj   +1 more source

Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto’s thyroiditis: a case report

Journal of Medical Case Reports, 2022
Background Latent autoimmune diabetes in adults is an infrequent form of autoimmune diabetes mellitus, while Hashimoto’s thyroiditis, the most common thyroid disease in adults, rarely manifests as thyrotoxicosis.
Maria Xenou, Ioannis Zoupas, Dimitrios Lygnos, Evangelos Fousteris   +3 more
doaj   +1 more source

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Nature Communications, 2021
Chlorpyrifos is a widely-used pesticide and a common residue on vegetables and fruits. Here the authors show that at non-neurotoxic doses, chlorpyrifos reduces energy expenditure, by inhibiting diet induced thermogenesis, and promotes obesity and insulin
Bo Wang, Evangelia E. Tsakiridis, Shuman Zhang, Andrea Llanos, Eric M. Desjardins, Julian M. Yabut, Alexander E. Green, Emily A. Day, Brennan K. Smith, James S. V. Lally, Jianhan Wu, Amogelang R. Raphenya, Krishna A. Srinivasan, Andrew G. McArthur, Shingo Kajimura, Jagdish Suresh Patel, Michael G. Wade, Katherine M. Morrison, Alison C. Holloway, Gregory R. Steinberg   +19 more
doaj   +1 more source

Association between hepatic steatosis and fibrosis with measures of insulin sensitivity in patients with severe obesity and type 2 diabetes - a cross-sectional study

BMC Gastroenterology, 2022
Background Obesity, non-alcoholic fatty liver disease (NAFLD) and insulin resistance are three pathological conditions highly correlated, but this relationship is not fully elucidated.
Kathrine Aglen Seeberg, Dag Hofsø, Heidi Borgeraas, John Olav Grimnes, Farhat Fatima, Lars Thomas Seeberg, Nils Petter Kvan, Marius Svanevik, Jens Kristoffer Hertel, Jøran Hjelmesæth   +9 more
doaj   +1 more source

Obesity [PDF]

The Lancet, 2005
Excess bodyweight is the sixth most important risk factor contributing to the overall burden of disease worldwide. 1.1 billion adults and 10% of children are now classified as overweight or obese. Average life expectancy is already diminished; the main adverse consequences are cardiovascular disease, type 2 diabetes, and several cancers.
David W, Haslam, W Philip T, James
  +7 more sources

Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes

Stem Cells International, 2022
Mitochondrial dysfunction in white adipose tissue is strongly associated with obesity and its metabolic complications, which are important health challenges worldwide.
Elena Herbers, Mimmi Patrikoski, Anita Wagner, Riikka Jokinen, Antti Hassinen, Sini Heinonen, Susanna Miettinen, Hilkka Peltoniemi, Eija Pirinen, Kirsi H. Pietiläinen   +9 more
doaj   +1 more source

Prevalence of childhood and adult obesity in the United States, 2011-2012.

Journal of the American Medical Association (JAMA), 2014
IMPORTANCE More than one-third of adults and 17% of youth in the United States are obese, although the prevalence remained stable between 2003-2004 and 2009-2010.
Cynthia L Ogden, M. Carroll, Brian K. Kit, K. Flegal   +3 more
semanticscholar   +1 more source