Results 91 to 100 of about 3,017,861 (368)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Love and Attachment [PDF]

, 2017
It is not uncommon for philosophers to name disinterestedness, or some like feature, as an essential characteristic of love. Such theorists claim that in genuine love, one’s concern for her beloved must be non-instrumental, non-egocentric, or even ...
Wonderly, Monique
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Working Smarter Not Harder: Oxytocin Increases Domestic Dogs’ (Canis familiaris) Accuracy, but Not Attempts, on an Object Choice Task

Frontiers in Psychology, 2019
The neuropeptide oxytocin (OT) has been shown to enhance dogs’ ability to perform an object choice task (OCT) involving the use of human pointing cues, when delivered intranasally.
Jessica Lee Oliva, Manuel Mengoli, Manuel Mengoli, Tiago Mendonça, Tiago Mendonça, Alessandro Cozzi, Patrick Pageat, Patrick Pageat, Camille Chabaud, Eva Teruel, Céline Lafont-Lecuelle, Cécile Bienboire-Frosini   +11 more
doaj   +1 more source

Advances of Observation and Study on Tall-object Lightning in Guangzhou over the Last Decade

应用气象学报, 2020
Comparing to the ground or low-object, tall-object is more likely to reach the threshold for the initiation of leader on its top due to the distortion and enhancement of electric field, therefore tall-object is not only easier to get struck by downward ...
Lü Weitao, Chen Lüwen, Ma Ying, Qi Qi, Wu Bin, Jiang Ruijiao   +5 more
doaj   +1 more source

Selectable towline spin chute system [PDF]

, 1991
An emergency spin recovery parachute is presented that is housed within a centrally mounted housing on the aft end of an aircraft and connected to a ring fitting within the housing.
Vairo, Daniel M., Whipple, Raymond D.
core   +1 more source

A Systems Theory Perspective [PDF]

, 1991
Aktualisierung: Am 12.
Bischof, Norbert, Gubler, Harry, Keller, Heidi, Lamb, Michael E.   +3 more
core   +2 more sources

Digital Attachment Objects: Parent-Child Media Conflict Among Children with and Without Sensory Diagnoses [PDF]

, 2022
Kristen Harrison, Halie Wenhold
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Size and emotion or depth and emotion? Evidence, using Matryoshka (Russian) dolls, of children using physical depth as a proxy for emotional charge [PDF]

, 2013
Background: The size and emotion effect is the tendency for children to draw people and other objects with a positive emotional charge larger than those with a negative or neutral charge.
A Cotterill, A Karmiloff-Smith, AL Nicholls, AS Winston, BH Pillow, D Strange, E Burkitt, E Burkitt, F Flanagan, G Thomas, H Cleeve, J Bowlby, J Perara, JS DeLoache, L Sechrest, M Cox, MDS Ainsworth, MV Cox, MV Cox, MV Cox, NH Freeman, RA Craddick, RP Jolley, RP Jolley, S Morra, T Baguley, T Baguley, T Fox, TE Joiner, TE Joiner, W Ives   +30 more
core   +1 more source