Results 31 to 40 of about 9,867 (261)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
HAK KEKAYAAN INTELEKTUAL SEBAGAI BENDA: PENELUSURAN DASAR PERLINDUNGAN HKI DI INDONESIA
Refleksi Hukum, 2015 Abstrak Hak Kekayaan Intelektual memberikan kewenangan hukum kepada seseorang untuk mendapat keuntungan dari karya intelektual yang diciptakan. Hal ini berimplikasi pihak lain, yang tanpa persetujuan, tidak diperbolehkan untuk mengambil keuntungan dari ...
Indirani Wauran-Wicaksono
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Doctoral Student’s Responsibility for Violation of Ethical Standards During Doctoral Studies
EIRP Proceedings, 2022 Intellectual property law enjoys the most expansive and branching evolution of the last century, both in terms of national regulations and in terms of signed international conventions and adopted Community directives, as evidenced even by established ...
Maria Cristiana Ieremie
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Development of the combined approach to the valuation of intellectual property objects
Technology audit and production reserves, 2022 The object of this research is a combined approach to the valuation of intellectual property. The paper compares the traditional approaches to valuation: profitable, market and cost, and identified the shortcomings of each. During the work the methods of analysis and synthesis of scientific literature were used to highlight the disadvantages and ...
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
On the issue of the turnover of artificial intelligence systems
Ученые записки Казанского университета: Серия Гуманитарные науки, 2022 This article studies various forms and methods of using artificial intelligence systems in civil legal relations. It also considers a correlation between the concepts of civil, economic, and digital civil turnover.
A.E. Tsareva
doaj +1 more source