Results 41 to 50 of about 379,526 (298)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Intellectual property as complex innovation projects component [PDF]

, 1997
The materials presented the possibilities development of intellectual property complex innovation projects modern highly effective science-based problems of improving the use of wastes of different industries on a complex enterprise that can provide all ...
Bethke, S., Geitz, M., Hanke, K., Hüning, M., Ischebeck, R., Menzel, J., TESLA Collaboration, Tonutti, M., von Walter, G.   +8 more
core   +2 more sources

HAK KEKAYAAN INTELEKTUAL SEBAGAI BENDA: PENELUSURAN DASAR PERLINDUNGAN HKI DI INDONESIA

Refleksi Hukum, 2015
Abstrak Hak Kekayaan Intelektual memberikan kewenangan hukum kepada seseorang untuk mendapat keuntungan dari karya intelektual yang diciptakan. Hal ini berimplikasi pihak lain, yang tanpa persetujuan, tidak diperbolehkan untuk mengambil keuntungan dari ...
Indirani Wauran-Wicaksono
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Objects of intellectual property rights: general terms of protection

Theory and Practice of Intellectual Property, 2021
Keywords: wine go and brown models, promises, sort of roslin that breed of twarin,trade marks (marks for goods), commerce (form) naymenuvannya, geographic significance,komertsiyna tamnytsya, computer programs Intellectual property is the result of human creativity: works of art and science, inventionsand utility models in all fields of human activity,
openaire   +4 more sources

The Doctoral Student’s Responsibility for Violation of Ethical Standards During Doctoral Studies

EIRP Proceedings, 2022
Intellectual property law enjoys the most expansive and branching evolution of the last century, both in terms of national regulations and in terms of signed international conventions and adopted Community directives, as evidenced even by established ...
Maria Cristiana Ieremie
doaj  

Интеллектуальная собственность как объект бухгалтерского учета: экономическая сущность и проблемы ее коммерциализации [PDF]

, 2017
INTELLECTUAL PROPERTY AS AN OBJECT OF ACCOUNTING: ECONOMIC ESSENCE AND ISSUES OF ITS COMMERCIALIZATION N. BOREIKOИнвестиционная привлекательность каждой страны в немалой степени зависит от возможности внедрения современных инновационных технологий ...
Борейко, Н. А.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Мотивування працівників до створення обʼєктів інтелектуальної власності [PDF]

, 2016
У статті обґрунтовано важливість дослідження особливостей мотивування працівників до створення об’єктів інтелектуальної власності. Встановлено, що в економічно розвинених країнах стимулюванню інтелектуальної діяльності працівників надається першорядне ...
Іваницька, С. Б.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source