Results 51 to 60 of about 9,867 (261)
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Žinių nuosavybės teisių apsauga verslo organizacijoje
Informacijos Mokslai, 2007 Straipsnyje aptariama verslo organizacijos þiniø nuosavybës teisinës apsaugos sistema. Verslo organizacijos þinias suvokiant kaip nematerialius objektus, teigiama savita iðreikðtø þiniø nuosavybës apsaugos galimybë intelektinës nuosavybës teisës normomis.
Marija Stonkienė
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Problems of Recognition of Scientific Discovery as Object of Intellectual Property [PDF]
Societas et Iurisprudentia, 2018 The paper analyses the problems which prevent the recognition of the scientific discoveries as the legitimate objects of intellectual property. The subjects of the research are the definition and characteristics of the scientific discovery in the ...
Andrey Alekseyevich Bogustov
doaj
Object of Misappropriation in an Authorship Crime and its Meaning for Qualification
Teisė, 2020 This article analyses one element of corpus delicti of misappropriation of authorship, criminalised in Lithuanian Criminal Code Article 191 – the object (or the protected good) of a crime.
Ramunė Steponavičiūtė
doaj +1 more source
INTELLECTUAL PROPERTY AS FIDUCIARY OBJECT IN BANKING INSTITUTION [PDF]
Sultan Agung Notary Law Review, 2020 Global Market Development today by the Industrial Revolution 4.0 brings influence to Intellectual Property (IP) in the fields of Economy, especially in getting loans at banks to increase the capital of a business, Intellectual Property (IP) is used as the object of Fiducia.
openaire +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
THEORETICAL ASPECTS OF INTELLECTUAL PROPERTY RESEARCH UNDER THE MODERN CONDITIONS
Russian Journal of Economics and Law, 2012 The article analyzes the main theoretical approaches towards intellectual property in the modern economics. The main directions of this category research in western literature are viewed.
A. A. Akhmetov
doaj
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +9 more
wiley +1 more source