Results 51 to 60 of about 544,930 (344)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pluralism about Knowledge [PDF]

, 2017
In this paper I consider the prospects for pluralism about knowledge, that is, the view that there is a plurality of knowledge relations. After a brief overview of some views that entail a sort of pluralism about knowledge, I focus on a particular kind ...
Berit Brogaard, Christoph Kelp, Crispin Wright, David Lewis, Ernest Sosa, Frank Jackson, Fred Dretske, Jason Stanley, Jennifer Lackey, Jennifer Nagel, Jeremy Fantl, Jessica Brown, John Hawthorne, John Hawthorne, John MacFarlane, Jonathan Schaffer, Keith DeRose, Klemens Kappel, Krista Lawlor, Laurence BonJour, Mark Kaplan, Markus Seidel, Michael Blome-Tillmann, Michael Hannon, Michael Lynch, Michael Williams, Mikkel Gerken, Nikola Kompa, Patrick Rysiew, Paul Boghossian, Richard Rorty, Stephen R Grimm, Stewart Cohen, Timothy Williamson, William Alston   +34 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The missing voices in the conscientious objection debate: British service users’ experiences of conscientious objection to abortion

BMC Medical Ethics, 2023
Background The fourth section of the 1967 Abortion Act states that individuals (including health care practitioners) do not have to participate in an abortion if they have a conscientious objection.
Becky Self, Clare Maxwell, Valerie Fleming   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Evaluation of Health Board Documents Referred to the Tertiary Hospital for Objection and Referral in Terms of Ophthalmology

Hamidiye Medical Journal
Background: Medical board examinations and scoring form a substantial part of the workload for specialized physicians in Türkiye. This study evaluates these tasks from the perspective of ophthalmology specialists and compares the ophthalmologic ...
Mehmet Egemen Karataş, Gamze Karataş
doaj   +1 more source

Causes for Conscientious Objection in Medical Aid in Dying: A Scoping Review

Canadian Journal of Bioethics, 2023
In the light of current legislation on Medical Aid in Dying ─euthanasia and assisted suicide─ in different countries worldwide, there have been some arguments devoted to the right to conscientious objection for healthcare professionals in these specific
Rosana Triviño-Caballero, Iris Parra Jounou, Isabel Roldán Gómez, Maria Teresa Lopez de la Vieja   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

An Examination of the Wisdoms of Abrogation (Naskh) in the Holy Qur’an

مجلۀ علمی-تحقیقی سمنگان
The discussion of abrogation (naskh), in addition to jurisprudence (fiqh) and the principles of jurisprudence (usul al-fiqh), is regarded as one of the significant branches of Qur’anic sciences.
Mehrabuddin shahab
doaj   +1 more source

The Deadline for Invoking the Frivolous Claim in Iranian Law (Looking at the Judicial Procedure) [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Khuṣūṣī
The demand for security for damages resulting from filing a false lawsuit is an institution to counter baseless and harassing lawsuits, which has also been considered by the Iranian legislator.
Mahdi Hamze Howeyda
doaj   +1 more source