Results 141 to 150 of about 22,537,611 (357)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Outlier Detection and Explanation Method Based on FOLOF Algorithm

Entropy
Outlier mining constitutes an essential aspect of modern data analytics, focusing on the identification and interpretation of anomalous observations. Conventional density-based local outlier detection methodologies frequently exhibit limitations due to ...
Lei Bai, Jiasheng Wang, Yu Zhou
doaj   +1 more source

Hierarchical Grouping to Optimize an Objective Function

, 1963
J. H. Ward
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Quality objectives in management systems – their attributes, establishment and motivational function [PDF]

, 2021
Marek Bugdol, Piotr Jedynak
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Optimization of the structure of the learning process under the given constraints

Системный анализ и прикладная информатика
The article is devoted to the study of ways to optimize the mathematical model of the structure of the educational process. Formalization of the structure of the educational process was carried out in the form of setting an objective function, including ...
A. A. Lobaty, D. A. Konopacki
doaj   +1 more source

OBJECTIVE FUNCTIONS OF THE COMPARATIVE ANALYSIS OF THE ENERGY EFFICIENCY OF ELECTROMAGNETIC SYSTEMS OF INDUCTION MOTORS WITH INNER AND OUTER ROTORS

, 2015
Andrey Stavinskii, O. О. Palchykov
openalex   +2 more sources

Objective Meat Quality and Volatile Components as a Function of Cooking Temperature in Beef Longissimus lumborum [PDF]

, 2010
Joong-Ryong Ji, Kyung-Mi Park, Ho Sung Choe, Inho Hwang   +3 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source