The Third Way on Objective Probability: A Skeptic's Guide to Objective Chance [PDF]
, 2005 The goal of this paper is to sketch and defend a new interpretation or theory of objective chance, one that lets us be sure such chances exist and shows how they can play the roles we traditionally grant them. The subtitle obviously emulates the title of
Hoefer, Carl, Carl Hoefer
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Scalarizing cost-effective multi-objective optimization algorithms made possible with kriging
, 2008 Purpose – The purpose of this paper is threefold: to make explicitly clear the range of efficient multi-objective optimization algorithms which are available with kriging; to demonstrate a previously uninvestigated algorithm on an electromagnetic design ...
Hawe, G., Sykulski, J.K.
core
Single Mathematical Parameter for Evaluation of the Microorganisms' Growth as the Objective Function in the Optimization by the DOE Techniques. [PDF]
Microorganisms, 2020 Konopacki M +5 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Third Way on Objective Probability: A Skeptic's Guide to Objective Chance [PDF]
, 2007 The goal of this paper is to sketch and defend a new interpretation or ‘theory’ of objective chance, one that lets us be sure such chances exist and shows how they can play the roles we traditionally grant them.
Hoefer, Carl
core
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015 During researches is proposed the model of the automated decision-making from substantiate of the strategic objectives for the subjects of the national security system (NSS).
Volodymyr Y. Bohdanovych +2 more
doaj
Knot selection in sparse Gaussian processes with a variational objective function. [PDF]
Stat Anal Data Min, 2020 Garton N, Niemi J, Carriquiry A.
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source