Results 131 to 140 of about 11,184,024 (281)
БАГАТОКРИТЕРІАЛЬНА ОПТИМІЗАЦІЯ ДИНАМІЧНИХ СИСТЕМ УПРАВЛІННЯ
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2014 У статті розглядаються динамічні системи управління. В таких системах критерій якості управління являє собою функціонал, визначений на її рішеннях. Екстремізація функціоналів є предметом варіаційного обчислення.
Albert M. Voronin +3 more
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
An objective function for full-waveform inversion based on frequency-dependent offset-preconditioning. [PDF]
PLoS One, 2020 da Silva SLEF +4 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2016 Mary A Dolansky,1 Julie T Schaefer,2 Misty AW Hawkins,3 John Gunstad,2 Anup Basuray,4 Joseph D Redle,5 James C Fang,6 Richard A Josephson,7,8 Shirley M Moore,1 Joel W Hughes2 1School of Nursing, Case Western Reserve University, Cleveland, OH, USA ...
Schaefer JT +9 more
core
, 1975 Since the early 1940s the field of operations research has played an increasingly important role. A prominent area in this field is that of optimization problems, particularly linear programming (LP). As early as 1939 Kantorovich recognized the importance of LP and made early contributions; but it was G.B.
openaire +1 more source
Objective function estimation for solving optimization problems in gate-model quantum computers. [PDF]
Sci Rep, 2020 Gyongyosi L.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source