Results 111 to 120 of about 11,184,024 (281)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Outlier Detection and Explanation Method Based on FOLOF Algorithm
EntropyOutlier mining constitutes an essential aspect of modern data analytics, focusing on the identification and interpretation of anomalous observations. Conventional density-based local outlier detection methodologies frequently exhibit limitations due to ...
Lei Bai, Jiasheng Wang, Yu Zhou
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
CONTROLLING IN THE FUNCTION OF MANAGEMENT BY OBJECTIVES
DIEM : Dubrovnik International Economic MeetingThe tasks given to management are becoming more demanding every day, requiring new knowledge and skills. Drucker's famous management by objectives has survived, but its essence is changing and adapting to new knowledge determined by the needs of management.
Piplica, Damir +2 more
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Optimization of the structure of the learning process under the given constraints
Системный анализ и прикладная информатикаThe article is devoted to the study of ways to optimize the mathematical model of the structure of the educational process. Formalization of the structure of the educational process was carried out in the form of setting an objective function, including ...
A. A. Lobaty, D. A. Konopacki
doaj +1 more source
Reactive Objects and Functional Programming.
, 1999 The construction of robust distributed and interactive software is still a challenging task, despite the recent popularity-increase for languages that take advanced programming concepts into the mainstream. Several problematic areas can be identified: most languages require the reactivity of a system to be manually upheld by careful avoidance of ...
openaire +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source