Results 121 to 130 of about 1,393,311 (289)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

An Objective Approach to Prior Mass Functions for Discrete Parameter Spaces

, 2015
We present a novel approach to constructing objective prior distributions for discrete pa- rameter spaces. These type of parameter spaces are particularly problematic, as it appears that common objective procedures to design prior distributions are ...
Villa C., C. Villa (823641), Villa, Cristiano, S. G. Walker (823642), Walker S. G., Walker, Stephen   +5 more
core   +1 more source

Semi-Supervised Fuzzy Clustering Based on Prior Membership

Mathematics
Traditional fuzzy clustering algorithms construct sample partition criteria solely based on similarity measures but lack an effective representation of prior membership information, which limits further improvements in clustering accuracy.
Yinghan Hong, Guoxiang Zhong, Jiahao Lian, Guizhen Mai, Honghong Zhou, Pinghua Chen, Junliu Zhong, Hui Cao   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The impact of prior radiation or chemotherapy on surgical outcomes in the treatment of spine metastases

Journal of Craniovertebral Junction and Spine
Study Design: This was a retrospective cohort study. Objective: The objective of this study was to evaluate the impact of prior chemotherapy and/or radiation on outcomes among patients undergoing surgery for spinal metastases. Summary of Background Data:
Alec Giakas, Joydeep Baidya, Jonathan Dalton, William A. Green, Mitchell Ng, Teeto Ezeonu, Rajkishen Narayanan, Yunsoo A. Lee, Perry Goodman, Eleanor Jenkins, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Organ‐Specific Responses to Nivolumab Plus Ipilimumab in Advanced Hepatocellular Carcinoma: A Multicenter, Retrospective Study

Cancer Medicine
Background Immune checkpoint inhibitor (ICI) monotherapy elicits limited intrahepatic responses in patients with advanced hepatocellular carcinoma (HCC). Here, we investigate the organ‐specific objective response rate (OSORR) of nivolumab plus ipilimumab
Jung Sun Kim, Youngun Kim, Beodeul Kang, Ilhwan Kim, Hyeyeong Kim, Won Suk Lee, Jung Yong Hong, Ho Yeong Lim, Han Sang Kim, Chang Gon Kim, Sanghoon Jung, Chansik An, Chan Kim, Hong Jae Chon   +13 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

3D Feature Distillation with Object-Centric Priors

Abstract Grounding natural language to the physical world is a ubiquitous topic with a widerange of applications in computer vision and robotics. Recently, 2D vision-languagemodels such as CLIP have been widely popularized, due to their impressivecapabilities for open-vocabulary grounding in 2D images.
Tziafas, Georgios, Xu, Yucheng, Li, Zhibin, Kasaei, Hamidreza   +3 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source