Results 131 to 140 of about 1,393,311 (289)

Mixtures of g-priors for bayesian model averaging with economic applications [PDF]

open access: yes
We examine the issue of variable selection in linear regression have a potentially large amount of possible covariates and economic theory offers insufficient guidance on how to select the Model Averaging presents uncertainty.
Eduardo Ley, Mark F.J. Steel
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Nonsubjective priors via predictive relative entropy regret

open access: yes, 2006
We explore the construction of nonsubjective prior distributions in Bayesian statistics via a posterior predictive relative entropy regret criterion. We carry out a minimax analysis based on a derived asymptotic predictive loss function and show that ...
Sweeting, TJ, Datta, GS, Ghosh, M
core  

Portfolios and meaning-making in the assessment of prior learning

open access: yes, 2013
The take-up of the Assessment of Prior Experiential Learning (APEL) by students in the UK remains low. In exploring why this might be the case, this article seeks to examine the process of preparing claims for APEL, with the objective of understanding ...
Pokorny, H.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The influence of student characteristics on the use of adaptive e-learning material

open access: yes, 2012
Adaptive e-learning materials can help teachers to educate heterogeneous student groups. This study provides empirical data about the way academic students differ in their learning when using adaptive elearning materials.
Seters, J.R., van   +3 more
core   +1 more source

Coevolutionary Algorithm with Bayes Theorem for Constrained Multiobjective Optimization

open access: yesMathematics
The effective resolution of constrained multi-objective optimization problems (CMOPs) requires a delicate balance between maximizing objectives and satisfying constraints.
Shaoyu Zhao   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Objective interpretation of the penalised complexity prior in copula models

open access: yes, 2019
In many statistical models it is natural to have a nested structure. Consider a model of a given complexity, one way to obtain a more flexible model is to include an extra component so that the simpler model would be nested in the more complex one ...
diego battagliese   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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