Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival. [PDF]
Neuro Oncol, 2023 Abstract Durable objective response rate (ORR) remains a meaningful endpoint in recurrent cancer; however, the target ORR for single-arm recurrent glioblastoma trials has not been based on historic information or tied to patient outcomes.
Ellingson BM +15 more
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Objective response rate assessment in oncology: Current situation and future expectations. [PDF]
World J Clin Oncol, 2020 The tumor objective response rate (ORR) is an important parameter to demonstrate the efficacy of a treatment in oncology. The ORR is valuable for clinical decision making in routine practice and a significant end-point for reporting the results of clinical trials.
Aykan NF, Özatlı T.
europepmc +3 more sources
Improving the Conversion Success Rate of Hepatocellular Carcinoma: Focus on the Use of Combination Therapy with a High Objective Response Rate. [PDF]
J Clin Transl HepatolThe high mortality rate in hepatocellular carcinoma (HCC) is partially due to the fact that a significant number of patients are diagnosed at an intermediate or advanced stage, with surgical treatment options unavailable. Conversion therapy, which involves both locoregional and systemic treatments, has the potential to downstage tumors in selected ...
Chen QF, Chen S, Chen M, Lyu N, Zhao M.
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Should high response rates really be a primary objective? [PDF]
Survey Practice, 2012 Many survey agencies tend to measure and express the quality of their respond ent samples in terms of response rates. Moreover, AAPOR advises in its best practices to “maximize cooperation or response rates […]” (www.aapor.org). Indeed, low nonresponse rates are believed to reduce the potential for nonresponse bias.
Beullens, Koen, Loosveldt, Geert
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Effect of experience sampling schedules on response rate and recall accuracy of objective self-reports [PDF]
International Journal of Human-Computer Studies, 2019 Abstract The Experience Sampling Method is widely used to collect human labelled data in the wild. Using this methodology, study participants repeatedly answer a set of questions, constructing a rich overview of the studied phenomena. One of the methodological decisions faced by researchers is deciding on the question scheduling.
Niels van Berkel +5 more
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Heart rate responses provide an objective evaluation of human disturbance stimuli in breeding birds [PDF]
Conservation Physiology, 2013 Intuition is a poor guide for evaluating the effects of human disturbance on wildlife. Using the endangered Yellow-eyed penguin, Megadyptes antipodes, as an example, we show that heart rate responses provide an objective tool to evaluate human disturbance stimuli and encourage the wider use of this simple and low-impact approach.
Ellenberg, Ursula +2 more
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Main factors associated with variability in the assessment of the objective response rate. A re-analysis of the PHEREXA phase 3 clinical trial. [PDF]
Br J Clin PharmacolAbstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single ...
Daniele G +3 more
europepmc +3 more sources
Extremely High Objective Response Rate of Lenvatinib: Its Clinical Relevance and Changing the Treatment Paradigm in Hepatocellular Carcinoma. [PDF]
Liver Cancer, 2018 The results of a clinical trial of lenvatinib were published in the Lancet earlier this year [1]. According to the results, the response rate was higher for lenvatinib than for any other known molecular targeted agents in hepatocellular carcinoma (HCC) patients. The response rates based on independent imaging review and investigator review according to
Kudo M.
europepmc +4 more sources
JGH Open, 2020 Purpose The aim of this study was to assess the effectiveness and safety of hepatic arterial infusion chemotherapy (HAIC) using the FOLFOX regimen combined with transarterial embolization (TAE + HAIC) in patients with unresectable hepatocellular ...
Wenbo Guo +5 more
doaj +1 more source
Predict progression free survival and overall survival using objective response rate for anti-PD1/PDL1 therapy development. [PDF]
BMC CancerAbstract Background: In anti - PD1 (programmed death-1) / PDL1 (programmed death ligand 1) therapy development for solid tumors, the objective response rate (ORR) is a commonly used clinical endpoint for early phase study decision making, while progression free survival (PFS) and overall survival (OS) are widely used for late phase study ...
Yang L +4 more
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