Results 211 to 220 of about 1,117,895 (256)
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Tumor Shrinkage and Objective Response Rates
The Cancer Journal, 2009Phase II clinical trials have long been used to screen new cancer therapeutics for antitumor activity ("efficacy") worthy of further evaluation. Traditionally, the primary end point used in these screening trials has been objective response rate (RR), with the desired rate being arbitrarily set by the researchers before initiation of the trial.
Penelope, Bradbury, Lesley, Seymour
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I/O Response Rate Analysis in the Replicate-Based Object Storage System
2010 Ninth International Symposium on Distributed Computing and Applications to Business, Engineering and Science, 2010With the development of storage technology, storage system capacity has been rapidly growing, so rapid that storage I/O performance has become one of the most critical issues in large complex systems. This article combines the latest research in object-based storage with replica technology to share I/O in the object storage system, and to maintain high
Zhipeng Tan +4 more
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Cancer Research, 2023
Abstract Background: Previous studies have shown that ctDNA MR defined by 50% reduction of ctDNA levels after immune checkpoint inhibitor (ICI) treatment is significantly associated with improved survival. However, discordance between MR and radiologic response was observed, hindering the potential use of MR as a surrogate endpoint.
Qu Zhang +6 more
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Abstract Background: Previous studies have shown that ctDNA MR defined by 50% reduction of ctDNA levels after immune checkpoint inhibitor (ICI) treatment is significantly associated with improved survival. However, discordance between MR and radiologic response was observed, hindering the potential use of MR as a surrogate endpoint.
Qu Zhang +6 more
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Objective Response Rate As a Surrogate End Point: A Commentary
Journal of Clinical Oncology, 2005Bruzzi et al have evaluated objective response rate (ORR) as a potential surrogate end point for survival in metastatic breast cancer patients. Throughout oncology, many biomarkers have been evaluated. Examples include direct measures of the tumor burden process, such as ORR or progression-free survival (PFS), or inherently less reliable indirect ...
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Journal of Gastroenterology and Hepatology, 2019
AbstractBackground and AimThe study aims to assess the influence of pretreatment tumor growth rate (TGR) on modified response evaluation criteria in solid tumors (mRECIST) objective response (OR) after a first session of selective transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC).MethodsOne hundred fifteen ...
Yvonne Purcell +4 more
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AbstractBackground and AimThe study aims to assess the influence of pretreatment tumor growth rate (TGR) on modified response evaluation criteria in solid tumors (mRECIST) objective response (OR) after a first session of selective transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC).MethodsOne hundred fifteen ...
Yvonne Purcell +4 more
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Abstract A21: Effect of forced-response on completion rate in objective Internet-based health survey
Cancer Epidemiology, Biomarkers & Prevention, 2020Abstract Introduction: Forced-response in Internet-based surveys is one solution to item nonresponse in population science research, but forced-response can inflate dropout rate and introduce bias. As a result, forced-response has been described as a trade-off between data quantity and data quality.
Lenna Dawkins-Moultin +2 more
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Controlled Clinical Trials, 1994
Gehan's two-stage procedure is commonly used in phase II clinical trials to enable one to stop a trial early if the observed response rate in the first stage does not warrant further study and to obtain an adequate estimate of response rate if the trial passes the first stage. However, when the response rate of interest is relatively high (0.3 or more),
S, Chen, S J, Soong, R H, Wheeler
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Gehan's two-stage procedure is commonly used in phase II clinical trials to enable one to stop a trial early if the observed response rate in the first stage does not warrant further study and to obtain an adequate estimate of response rate if the trial passes the first stage. However, when the response rate of interest is relatively high (0.3 or more),
S, Chen, S J, Soong, R H, Wheeler
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Investigational New Drugs
This study retrospectively analyzed the curative effect of neoadjuvant PD-1 inhibitors combined with chemotherapy of locally advanced laryngeal and hypopharyngeal cancer and compared with chemotherapy plus EGFR inhibitors and chemotherapy alone. From January 1 2018 to October 1 2023, a total of 113 patients in Beijing Tongren Hospital, who were ...
Shaoshi, Chen +10 more
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This study retrospectively analyzed the curative effect of neoadjuvant PD-1 inhibitors combined with chemotherapy of locally advanced laryngeal and hypopharyngeal cancer and compared with chemotherapy plus EGFR inhibitors and chemotherapy alone. From January 1 2018 to October 1 2023, a total of 113 patients in Beijing Tongren Hospital, who were ...
Shaoshi, Chen +10 more
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