Results 71 to 80 of about 1,117,895 (256)

Comparison of Short-term Efficacy of Neoadjuvant Immunotherapy Combined with Chemotherapy and Surgery Alone for Locally Advanced Resectable 
Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer
Background and objective Lung cancer is the cancer with the highest incidence and mortality rates in China, and non-small cell lung cancer (NSCLC) accounts for 80%-85% of all malignant lung tumors.
Haitian LI, Qing LIU, Bin LI, Yuzhen CHEN, Junping LIN, Yuqi MENG, Haiming FENG, Zhizhong ZHENG, Yiming HUI   +8 more
doaj   +1 more source

Neoadjuvant treatment in locally advanced thyroid cancer: a single institution experience

Frontiers in Oncology
BackgroundLocally advanced thyroid cancer is a kind of aggressive malignancy with poor overall survival (OS). Neoadjuvant therapy has shown a certain efficacy in locally advanced thyroid cancer.
Ling-Feng Xu, Nuo Shi, Jia-Liang Niu, Ning An, Yi-Qing Xi, Qiu-Yi Huang, Liang Jiang, Jian Chen   +7 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Selinexor in combination with dexamethasone with or without bortezomib in heavily pretreated multiple myeloma: A case series

eJHaem
This report describes the characteristics and outcomes of 18 heavily pretreated patients with multiple myeloma (MM) who were subsequently treated with selinexor.
Nini Aung, Margaret Bowers, Gillian Brearton, Andrew Charlton, Joanne Craig, Jonathan Cullis, Ray Dang, David Donaldson, Mary Drake, Rachel Hall, Elizabeth Parkins, Jane Tighe, Ceri Bygrave, Oonagh Sheehy   +13 more
doaj   +1 more source

Balloon-occluded hepatic arterial infusion for unresectable hepatocellular carcinoma: a phase II trial interim analysis

Frontiers in Oncology
BackgroundHepatic arterial infusion chemotherapy (HAIC) is increasingly used to treat unresectable hepatocellular carcinoma (HCC), yet some HCC patients remain unresponsive or show disease progression.PurposeThis phase II study (ChiCTR2300077718) aimed ...
Feng Li, Jian Zhang, Xiangbo An, Jianfei Liu, Benkei Li, Haiwei Li, Li Jun, Ningfang Wang, Guinan Jiang, Ye Jiang, Dehui Zhang, Fei Gao, Lei Song, Jun Zhou, Wenheng Zheng, Min Ji, Feng Wang   +16 more
doaj   +1 more source

Camrelizumab combined with microwave ablation improves the objective response rate in advanced non-small cell lung cancer

Journal of Cancer Research and Therapeutics, 2019
The present study evaluated the safety and efficacy of camrelizumab (a programmed death-1 antibody) in combination with microwave ablation (MWA) in advanced non-small cell lung cancer (NSCLC).A total of 21 patients were prospectively enrolled. MWA was performed in 25 pulmonary lesions during 21 sessions. Camrelizumab was administered 5-7 days after MWA
Zhigang, Wei, Xia, Yang, Xin, Ye, Guanghui, Huang, Wenhong, Li, Xiaoying, Han, Jiao, Wang, Min, Meng, Yang, Ni, Zhigeng, Zou, Qiang, Wen   +10 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Immune checkpoint inhibitor–based combination therapy for platinum-resistant or platinum-refractory recurrent ovarian cancer: a systematic review and meta-analysis of prospective trials

Frontiers in Oncology
BackgroundThe clinical value of immune checkpoint inhibitor (ICI)-based combinations in platinum-resistant or platinum-refractory recurrent ovarian cancer remains regimen-dependent and uncertain.
Jing Xu, Jing Xu, Lin Zhang, Wen-Ying Yang, Xiao-Jing Cai, Xiong Xiao   +5 more
doaj   +1 more source