Results 131 to 140 of about 371,247 (318)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

panTB-HM: a multi-arm clinical trial of a pan-TB regimen targeting both host and microbe

Trials
Background Newer oxazolidinones will be required to advance regimens in pan-TB indications. The addition of host-directed agents may help promote the recovery of lung function during TB treatment and prevent post-TB lung disease.
D. Mudzengi, S. Mashatole, Q. Xiang, C. Adrion, N. Glover, T. Ngwanto, J. Mdluli, S. Boniface, M. Rassool, B. Matome, L. Paramo, E. Svensson, A. Fasanmi, S. Angelo, M. Moyo, C. Marx, C. Khosa, L. Mokaba, N. Mofokeng, J. Lalashowi, C. Nacy, S. Charalambous, E. Fumane, V. Maphossa, T. Beattie, W. Brumskine, C. Venter, D. Mapamba, N. Heinrich, S. Rajaram, S. Kooverjee, L. Botha, M. Nell, A. Easton, S. Foraida, Robin Mark Warren, Issa Sabi, N. Ntinginya, R. S. Wallis, panTB-HM Consortium   +39 more
doaj   +1 more source

Obstructive Sleep Apnea and Ischemic Stroke Etiology: Is There a Link?

Sleep Science
Objectives The objective of this study is to evaluate the presence of obstructive sleep apnea (OSA) and its potential association with subtypes of stroke according to the classification of the Trial of Org 10172 in Acute Stroke Treatment (
Ana Claudia Crispiniano Siqueira Torquato, Silvana Sobreira Santos, Luciano Ferreira Drager, Rodrigo Pinto Pedrosa   +3 more
doaj   +1 more source

Objective data trials are needed [PDF]

BMJ, 1996
George Davey Smith, Yoav Ben-Shlomo
openaire   +1 more source

Cartel deterrence and settlements: the brazilian experience [PDF]

Settlements are an important part of a program of cartel deterrence, particularly when the likelihood ofconviction and the litigation costs are higher.
Henriksen, Alexandre Lauri, Azevedo, Paulo Furquim de   +1 more
core  

A comparison of empiric to physician-tailored programming of implantable cardioverter-defibrillators: results from the prospective randomized multicenter EMPIRIC trial

, 2006
OBJECTIVES: The purpose of this randomized study was to determine whether a strategically chosen standardized set of programmable settings is at least as effective as physician-tailored choices, as measured by the shock-related morbidity of implantable ...
Sterns, Laurence D., Morgan, John M., Wang, Zengri J., Ousdigian, Kevin T., Wilson, Ryan D., Wilkoff, Bruce L., EMPIRIC Trial Investigators, None   +6 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration

, 2008
BACKGROUND: Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the ...
Hopewell, S, Douglas G Altman, Moher, D., Mike Clarke, Schulz, KF, Hopewell, S., Wager, E., Philippa Middleton, The, CG, Sally Hopewell, Schulz, K., Moher, D, Altman, DG, CONSORT Group, Middleton, P, Clarke, M., Hopewel, S, Kenneth F Schulz, Elizabeth Wager, Wager, E, Middleton, P., Hopewell, Sally, David Moher, Altman, D., null null, Clarke, Michael, Clarke, M   +26 more
core   +1 more source