Results 111 to 120 of about 371,247 (318)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Acupuncture for pain and osteoarthritis of the knee: a pilot study for an open parallel-arm randomised controlled trial

BMC Musculoskeletal Disorders, 2009
Background There is some evidence that acupuncture for pain and osteoarthritis (OA) of the knee is more than a placebo, and short term clinical benefits have been observed when acupuncture is compared to usual care. However there is insufficient evidence
Brealey Stephen, Howard Katie, Lansdown Harriet, MacPherson Hugh   +3 more
doaj   +1 more source

Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo [PDF]

, 2016
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate.
Lengeler, Christian, Henry M. T. Ntuku, Tshefu, Antoinette K., Christian Lengeler, Ntuku Et Al. Malar J, Christian Burri, Antoinette K. Tshefu, Kalemwa, Didier M., Henry M. T. Ntuku, Gianfrancesco Ferrari, Burri, Christian, Didier M. Kalemwa, Ferrari, Gianfrancesco, Ntuku, Henry M. T.   +13 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Hospital admissions in older people with visual impairment in Britain. [PDF]

, 2008
BACKGROUND: We aimed to assess the risk of hospital admission associated with visual impairment in a representative sample of older people living in the community in Britain. DESIGN: Prospective study of hospital admission in a population-based sample of
Astrid E Fletcher, Evans, Jennifer R, Evans Jennifer R, Smeeth, Liam, Fletcher, Astrid E, Smeeth Liam, Jennifer R Evans, Fletcher Astrid E, Liam Smeeth   +8 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Involving patients and clinicians in the development of a randomised clinical trial protocol to assess spinal manual therapy versus nerve root injection for patients with lumbar radiculopathy: a patient and public involvement project to inform the SALuBRITY trial design

Research Involvement and Engagement
Background Spinal manual therapy and corticosteroid nerve root injection are commonly used to treat patients with lumbar radiculopathy. The SALuBRITY trial—a two parallel group, double sham controlled, randomised clinical trial—is being developed to ...
Corina Ryf, Léonie Hofstetter, Lauren Clack, Cesar A. Hincapié   +3 more
doaj   +1 more source

Transparency of Outcome Reporting and Trial Registration of Randomized Controlled Trials Published in the Journal of Consulting and Clinical Psychology

, 2015
Confidence that randomized controlled trial (RCT) results accurately reflect intervention effectiveness depends on proper trial conduct and the accuracy and completeness of published trial reports. The Journal of Consulting and Clinical Psychology (JCCP)
Brett D Thombs, Thombs, Brett, Riehm, Kira, Azar, Marleine, Marleine Azar, Brett D. Thombs (105019), Marleine Azar (828349), McKay, Dean, Dean McKay (828351), Kira E. Riehm (828350), Kira E Riehm, Dean McKay, Riehm, Kira E.   +12 more
core   +1 more source

Design of a phase III multicenter trial to evaluate the efficacy of the RTS,S/AS01 malaria vaccine in children across diverse transmission settings in Africa. [PDF]

, 2011
BACKGROUND\ud \ud GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative are working in partnership to develop a malaria vaccine to protect infants and children living in malaria endemic regions of sub-Saharan Africa, which can be delivered ...
Amanda Leach, Vekemans Johan, Savarese Barbara, Abdulla, Salim, Loucq, Christian, Salim Abdulla, Cahill Conor, Owusu-Agyei, Seth, Macete, Eusebio, Lievens Marc, Njuguna, Patricia, Marc Lievens, Christian Loucq, Ofori-Anyinam Opokua, Leach, Amanda, Njuguna Patricia, Vekemans, Johan, Patricia Njuguna, Cahill, Conor, Macete Eusebio, Barbara Savarese, Savarese, Barbara, Seth Owusu-Agyei, Owusu-Agyei Seth, Opokua Ofori-Anyinam, Ballou, W Ripley, Abdulla Salim, Clinical Trials Partnership Committee, Lievens, Marc, Ofori-Anyinam, Opokua, null null, Leach Amanda, Eusebio Macete, Conor Cahill, Ballou W Ripley, Loucq Christian, Johan Vekemans, W Ripley Ballou   +37 more
core   +1 more source