Results 101 to 110 of about 371,247 (318)

Improvement in neonatal intensive care unit care: a cluster randomised controlled trial of active dissemination of information. [PDF]

, 2011
BACKGROUND: Research findings are not rapidly or fully implemented into policies and practice in care. OBJECTIVES: To assess whether an 'active' strategy was more likely to lead to changes in policy and practice in preterm baby care than traditional ...
Allen, Elizabeth, Costeloe, Kate, D. Elbourne, Acolet, Dominique, E. Allen, R. Houston, A. R. Wilkinson, K. Costeloe, Houston, Rosie, D. Acolet, Elbourne, Diana, Wilkinson, Andrew R   +11 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Designing trials with multiple objectives with graphical approach for multiple scenarios

Contemporary Clinical Trials Communications
Clinical trials with multiple objectives require careful control of the overall error rate through adjustments for multiple hypothesis testing. Design optimization must account for these adjustments across various plausible scenarios.
A. Adam Ding, Yulin Li, Samuel S. Wu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Use of Rasch analysis to refine a patient-reported questionnaire on satisfaction with communication of the multiple sclerosis diagnosis.

, 2014
The Comunicazione medico-paziente nella Sclerosi Multipla - Revised (COSM-R) is a patient self-assessed questionnaire probing the moment of multiple sclerosis (MS) diagnosis disclosure (section 1, five items) and following period (section 2, 15 items ...
Giordano A, Agorà studies, Solari A, Grzeda M, MATTAROZZI, KATIA, Tesio L, D'ALESSANDRO, ROBERTO, Simone A, on behalf of the SIMS Trial, SIMS Practice   +8 more
core   +1 more source

A randomised controlled trial of postoperative radiotherapy following breast-conserving surgery in a minimum-risk older population. The PRIME trial. [PDF]

, 2007
OBJECTIVES: To assess whether omission of postoperative radiotherapy in women with 'low-risk' axillary node negative breast cancer (T0-2) treated by breast-conserving surgery and endocrine therapy improves quality of life and is more cost-effective ...
van der Pol, M, Goh, TT, M van der Pol, Williams, LJ, R Lindley, Prescott, RJ, Kunkler, IH, C King, King, CC, Lindley, R, Jack, W, W Jack, I Kunkler, J Cairns, L Williams, T Goh, Cairns, J, R Prescott   +17 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial

BMJ Open
Objectives Clinical trials are needed to advance interventions such as chemoprevention that have potential to reduce the risk of malignant transformation in individuals with oral potentially malignant disorders.
Bridget Young, J Perry, Caroline McCarthy, Stefano Fedele, R Shaw, Frances Sherratt, Albert Jiménez-Tomàs, R Kuruvilla, M W Ho, M Daunt, S Moorhouse   +10 more
doaj   +1 more source

Reconceptualising the objectives of a pilot study for clinical research

, 2003
This is a methodological study in which a case report is used to retrospectively analyse the link between a successful pilot study and stalled main study to identify potential methodological weaknesses in the planning process.
MacLellan, Lorna, Osborne, Sonya, Gardner, Glenn, Gardner, Glenn E., Gardner, Anne   +4 more
core   +1 more source