Results 81 to 90 of about 371,247 (318)

Measuring skin necrosis in a randomised controlled feasibility trial of heat preconditioning on wound healing after reconstructive breast surgery: study protocol and statistical analysis plan for the PREHEAT trial

Pilot and Feasibility Studies, 2018
Background Essential strategies are needed to help reduce the number of post-operative complications and associated costs for breast cancer patients undergoing reconstructive breast surgery.
Suzie Cro, Saahil Mehta, Jian Farhadi, Billie Coomber, Victoria Cornelius   +4 more
doaj   +1 more source

Objectives of Pre-Trial Procedure

, 1956
Pre-trial procedure in this country came into its own in 1938 with the adoption of the Federal Rules of Civil Procedure and its famous Rule 16. As the original notes to that rule point out, pre-trial had previously been in use in certain courts, notably ...
Clark, Charles
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Associate Principal Investigators and the HEAL-COVID trial: good for trainees, good for trials

Trials
Background The NIHR’s Associate Principal Investigator (API) Scheme in the United Kingdom was expanded nationally in 2020 with the aim of training clinicians to become Principal Investigators for clinical research in the future.
Joseph Newman, Philip Wild, HEAL-COVID Collaboration, Charlotte Summers, Mark Toshner   +4 more
doaj   +1 more source

Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol

BMJ Open
Introduction Cardiac rehabilitation (CR) delivered by rehabilitation specialists in a healthcare setting is effective in improving functional capacity and reducing readmission rates after cardiac surgery. It is also associated with a reduction in cardiac
Enoch Akowuah, Thanos Athanasiou, Rebecca Maier, Christopher Wilkinson, Emmanuel Ogundimu, Lisa Chang, Pasan Witharana   +6 more
doaj   +1 more source

Exploring different objectives in non-inferiority trials

BMJ
Non-inferiority trials compare the efficacy of a new treatment with an existing one where the new treatment is expected to have broadly similar efficacy to the existing treatment, but where other benefits might make the new treatment desirable. These trials might aim to demonstrate that a new treatment is either an alternative to, or a replacement for,
Conor D Tweed, Matteo Quartagno, Michelle N Clements, Rebecca M Turner, Andrew J Nunn, David T Dunn, Ian R White, Andrew J Copas   +7 more
openaire   +3 more sources

Conducting a trial of web conferencing software: why, how, and perceptions from the coalface [PDF]

, 2008
This paper reports on the trial of web conferencing software conducted at a regional Australian university with a significant distance population. The paper shares preliminary findings, the views of participants and recommendations for future activity ...
Loch, Birgit, Reushle, Shirley
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Objectives and outcomes of a clinical trial

Indian Journal of Anaesthesia, 2023
Mukul C Kapoor, Rakhee Goyal
openaire   +3 more sources

Short Oral Antibiotic Therapy for Pediatric Febrile Urinary Tract Infections: A Randomized Trial [PDF]

Background and objectives: Febrile urinary tract infection (fUTI) in well-appearing children is conventionally treated with a standard 10-day course of oral antibiotic.
Montini, Giovanni, Ronfani, Luca, Barbi, Egidio, Pennesi, Marco, STOP Trial Group, Console, Karen, Tessitore, Antimo   +6 more
core   +1 more source