Results 71 to 80 of about 371,247 (318)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Sessions of acupuncture and nutritional therapy evaluation for atrial fibrillation (Santé-AF): a randomised feasibility study

Pilot and Feasibility Studies
Background Atrial fibrillation is a common cardiac arrhythmia, associated with debilitating symptoms and a decrease in health-related quality of life. Current treatments for atrial fibrillation may not provide symptomatic relief and are associated with ...
Karen Charlesworth, David J. Torgerson, Judith M. Watson   +2 more
doaj   +1 more source

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 3; peer review: 3 approved, 1 approved with reservations]

NIHR Open Research
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values ...
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden   +26 more
doaj   +1 more source

Experiences of participants in a clinical trial of a novel radioactive treatment for advanced prostate cancer: A nested, qualitative longitudinal study

, 2022
OBJECTIVES: Qualitative studies nested within clinical trials can provide insight into the treatment experience, how this evolves over time and where improved supportive care is required.
Davis, ID, Ralph, N, Dunn, J, Hofman, MS, Dhillon, HM, Viljoen, Bianca, Davis, Ian D., Dunn, Jeff, Dhillon, Haryana M., Ralph, Nicholas, Chambers, Suzanne K., Hofman, Michael S., Chambers, SK, Viljoen, B   +13 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 2; peer review: 2 approved]

NIHR Open Research
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values ...
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden   +26 more
doaj   +1 more source

The current use of feasibility studies in the assessment of feasibility for stepped-wedge cluster randomised trials: a systematic review

BMC Medical Research Methodology, 2019
Background Stepped-wedge cluster randomised trials (SW-CRTs) are a pragmatic trial design, providing an unprecedented opportunity to increase the robustness of evidence underpinning implementation and quality improvement interventions.
Caroline A. Kristunas, Karla Hemming, Helen Eborall, Sandra Eldridge, Laura J. Gray   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A feasibility randomised controlled trial of Empowered Conversations: training family carers to enhance their relationships and communication with people living with dementia

Pilot and Feasibility Studies
Background The primary objective of this UK-based trial was to investigate the feasibility of conducting a multi-centre randomised controlled evaluation trial of Empowered Conversations (EC). EC is a 6-session group psychosocial intervention for informal
Lydia Morris, Cassie Eastham, Chris Sutton, Yeliz Prior, Yvonne Sylvestre, Gemma Shields, John Keady, Cathy Riley, Mal Walters, Warren Mansell   +9 more
doaj   +1 more source

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol [version 1; peer review: 2 approved]

NIHR Open Research
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and values ...
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden   +26 more
doaj   +1 more source